Journal: Drug Invention Today

Article Id: JPRS-P'Col-00005431
Title: Study on anti-inflammatory potential of crude aqueous leaf extract of Pterocarpus marsupium
Category: Pharmacology
Section: Research Article
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    Aim: This study aims to analyze the anti-inflammatory property of crude aqueous leaf extract of Pterocarpus marsupium (PM). Introduction: PM belong to the Fabaceae family. The useful parts of this plant are leaves, heartwood, flowers, and gum. It is odorless, astringent in taste, and sticks in the teeth coloring saliva red in color. PM is widely used in Ayurveda and Rasayana for the management of various metabolic disorders. All active principles of PM are thermostable. Materials and Methods: The collected leaves of PM are well dried, powdered to prepare the crude aqueous leaf extract, and then subjected to albumin denaturation assay and human red blood cell (HRBC) membrane stabilization method to analyze the anti-inflammatory activity of PM. Results: By doing albumin denaturation assay, maximum inhibition of 78% was observed at 0.4 mg/ml. Diclofenac, a standard anti-inflammation drug, showed the maximum inhibition of 80% at the concentration of 0.4 mg/ml. Followed by HRBC membrane stabilization method, PM exhibited effective anti-inflammatory activity by inhibiting hemolysis to a greater extent. Maximum inhibition of 82% was noted at 0.5 mg/ml while diclofenac showed maximum inhibition of 87% at 0.5 mg/ml. Conclusion: Inflammation is the body’s natural defense mechanism. At times, it becomes negative as it prolongs the treatment time. From this study, it is evident that PM possess anti-inflammatory properties.

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    Author(s) Name:

    K. Janani, R. Gayathri*, V. Vishnu Priya

    Affiliation(s) Name:

    Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: R. Gayathri, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 160, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    K. Janani, R. Gayathri*, V. Vishnu Priya

    Title:Study on anti-inflammatory potential of crude aqueous leaf extract of Pterocarpus marsupium
    Journal:Drug Invention Today
    Vol(issue):14 (March)
    Year:2020
    Page No: (59-62)
  • Experimental Methods Keywords

    Methodology:Anti-inflammatory activity,
    Research Materials: Pterocarpus marsupium

Keywords

Anti-inflammatory activity Crude aqueous extract Pterocarpus marsupium

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