Journal: Drug Invention Today

Article Id: JPRS-P'Col-00005434
Title: Study on the effect of piperine on carbohydrate metabolic enzymes on experimental diabetic rats
Category: Pharmacology
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Background: Type II diabetes mellitus is an increasingly prevalent disorder worldwide. India is reported to be the diabetic capital of the world. The contemporary treatment for type II diabetes involves insulin and drug therapies. The conventional drugs used are not able to cope to the multifactorial exhibit of type II diabetes. The administration of medicinal plants either alone or in addition to conventional drugs has been shown to address the causes of type II diabetes at various levels and improve the quality of diabetic patients. Aim: The present study was aimed at assessing the effect of piperine on carbohydrate metabolizing enzymes in experimental diabetic rats. Materials and Methods: Adult male albino rats of Wistar strain 150– 180 days old with 180–120 g of body weight were randomly divided into four groups of six rats each: Group 1: Normal rats, Group 2: Type 2 diabetic rats, Group 3: Type 2 diabetic rats treated with piperine (40 mg/kg for orally for 30 days), and Group 4: Type 2 diabetic rats treated with metformin 50 mg/kg orally for 30 days. Results: The activity of glucokinase and glycogen synthase was reduced conversely the activity of glycogen phosphorylase and glycogen-6-phosphatase which were increased significantly (P < 0.05). Oral administration of piperine significantly normalized (P < 0.05) altered levels of these enzymes to that of control and standard drug metformin level. Conclusion: Our present findings conclude that piperine possesses hypoglycemic activity through the regulation of carbohydrate metabolic enzymes. Further studies on the possible role of piperine on insulin signaling molecules are warranted.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    B. Kiran Srinivas, J. Selvaraj*, V. Vishnu Priya, R. Gayathri

    Affiliation(s) Name:

    Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    B. Kiran Srinivas, J. Selvaraj*, V. Vishnu Priya, R. Gayathri

    Title:Study on the effect of piperine on carbohydrate metabolic enzymes on experimental diabetic rats
    Journal:Drug Invention Today
    Vol(issue):14 (March)
    Year:2020
    Page No: (76-79)
  • Experimental Methods Keywords

    Methodology:Carbohydrate metabolic enzymes, High-fat diet, Type-2 diabetes
    Research Materials:Piperine

Keywords

Carbohydrate metabolic enzymes High-fat diet Piperine Type-2 diabetes

Our Services

Most Downloaded List