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Abstract

Background: Type II diabetes mellitus is an increasingly prevalent disorder worldwide. India is reported to be the diabetic capital of the world. The contemporary treatment for type II diabetes involves insulin and drug therapies. The conventional drugs used are not able to cope to the multifactorial exhibit of type II diabetes. The administration of medicinal plants either alone or in addition to conventional drugs has been shown to address the causes of type II diabetes at various levels and improve the quality of diabetic patients. Aim: The present study was aimed at assessing the effect of piperine on carbohydrate metabolizing enzymes in experimental diabetic rats. Materials and Methods: Adult male albino rats of Wistar strain 150– 180 days old with 180–120 g of body weight were randomly divided into four groups of six rats each: Group 1: Normal rats, Group 2: Type 2 diabetic rats, Group 3: Type 2 diabetic rats treated with piperine (40 mg/kg for orally for 30 days), and Group 4: Type 2 diabetic rats treated with metformin 50 mg/kg orally for 30 days. Results: The activity of glucokinase and glycogen synthase was reduced conversely the activity of glycogen phosphorylase and glycogen-6-phosphatase which were increased significantly (P < 0.05). Oral administration of piperine significantly normalized (P < 0.05) altered levels of these enzymes to that of control and standard drug metformin level. Conclusion: Our present findings conclude that piperine possesses hypoglycemic activity through the regulation of carbohydrate metabolic enzymes. Further studies on the possible role of piperine on insulin signaling molecules are warranted.

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	JPR Solutions

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