Journal: Drug Invention Today

Article Id: JPRS-P'Col-00005445
Title: Comparative evaluation of antimicrobial efficacy and cytotoxicity of nanohydroxyapatite reinforced particles and Vitamin D incorporated nanohydroxyapatite particles: An in vitro study
Category: Pharmacology
Section: Research Article
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    Introduction: The increasing prevalence of dental problems necessitates the development of novel preventive dental materials with supreme antimicrobial efficacy to reduce global disease burden. Hence, the aim of this study was to comparatively evaluate the antimicrobial efficacy and cytotoxicity of nanohydroxyapatite reinforced particles and Vitamin D incorporated nanohydroxyapatite particles. Materials and Methods: An in vitro experimental study was carried on three groups, namely, Group I: Nanohydroxyapatite prepared using black tea as reducing agent, Group-II: Commercially available Vitamin D powder using ethanol as solvent, and Group III and Group IV: Nanoformulation which comprised a combination of nanohydroxyapatite reinforced particles with 100 and 500 mg of Vitamin D dissolved in 3 ml of ethanol. Results: It was found that Group-II which comprised pure Vitamin D exhibited superior antimicrobial effect but was observed to be having cytotoxic effect. However, Group IV – nanoformulation with 500 mg of Vitamin D dissolved in 3 ml of ethanol showed a superior antimicrobial effect than Group I and inferior such effect when compared to Group II without demonstration of cytotoxic effects. Group IV is statistically significant at all different concentrations with P < 0.01. It was also observed that Group III and Group IV showed higher antimicrobial effect at a concentration of 100 than any other groups against Streptococcus mutans with statistical significance. Conclusion: The nanoformulation prepared which contained nanohydroxyapatite reinforced particles with 500 mg Vitamin D had supreme antimicrobial efficacy with no cytotoxic effects than any other groups.

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    Author(s) Name:

    S. Shree Lakshmi, D. Srisakthi Doraikannan*, I. Meignana Arumugham Indiran

    Affiliation(s) Name:

    Department of Public Health Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: D. Srisakthi Doraikannan, Department of Public Health Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, No: 162, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    S. Shree Lakshmi, D. Srisakthi Doraikannan*, I. Meignana Arumugham Indiran

    Title:Comparative evaluation of antimicrobial efficacy and cytotoxicity of nanohydroxyapatite reinforced particles and Vitamin D incorporated nanohydroxyapatite particles: An in vitro study
    Journal:Drug Invention Today
    Vol(issue):13 (March)
    Year:2020
    Page No: (206-208)
  • Experimental Methods Keywords

    Methodology: antimicrobial efficacy,Cytotoxicity
    Research Materials:Black tea,

Keywords

Antimicrobial Black tea Cytotoxicity Nanohydroxyapatite Preventive dentistry Vitamin D

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