Journal: Drug Invention Today
Title: Study on the effect of piperine on gluconeogenic enzymes in the liver of type-2 diabetic rats
Category: Pharmacology
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
Aim: The study was designed to assess the effect of piperine on gluconeogenic enzymes in high-fat diet-induced type-2 diabetic rats. Experimental Design: Adult male Wistar rats were used and divided as Group I: Control; Group II: Type-2 diabetic rats; Group III: Type-2 diabetic rats treated with piperine (40 mg/kg body weight [b.wt]/day, orally for 30 days); and Group IV: Type-2 diabetic rats treated with metformin (50 mg/kg b.wt/day, orally for 30 days). After 30 days of treatment, animals were anesthetized; liver tissues were dissected out and used for the assessment of gluconeogenic enzymes such as glucose- 6-phosphatase and phosphoenolpyruvate carboxykinase (PEPCK) Results: In diabetic animals, glucose-6-phosphatase and PEPCK activity were significantly raised (P < 0.05) compared with control animals. Oral administration of the piperine reduced the activity of these enzymes (P < 0.05) to that of the control and standard drug metformin. Conclusion: The present study shows that piperine possesses antidiabetic activity by reducing gluconeogenic enzymes in the liver.
-
Abstract Audio
No Audio file found
About the authors and Affiliations
Author(s) Name: B. Sachin Aditya, J. Selvaraj*, V. Vishnu Priya, R. Gayathri
Affiliation(s) Name: Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
*Corresponding author: J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.
-
View Article File in pdf format.
Article File
-
View Article Citation Here.
0 View More -
How to Cite my Article.
Author: B. Sachin Aditya, J. Selvaraj*, V. Vishnu Priya, R. Gayathri
Title: Study on the effect of piperine on gluconeogenic enzymes in the liver of type-2 diabetic rats Journal: Drug Invention Today Vol(issue): 13 (February ) Year: 2020 Page No: (216-219) -
Experimental Methods Keywords
Methodology: Glucose-6-phosphatase, Phosphoenolpyruvate carboxykinase Research Materials: Piperine
Keywords
Our Services
- Awareness on soil pollution among school students
- Complications of diabetes mellitus: A review
- Application of nanotechnology for Ayurvedic drugs and formulations
- Biodegradable plastic production from corn starch
- Effect of Kapalbhati Pranayama in the blood sugar level in diabetic patients
- Formulation and evaluation of Aloe vera gels
- Review On: Fast Dissolving Tablet
- Awareness of effects of sleep deprivation among college students
- Citric acid production from cane molasses using submerged fermentation by Aspergillus niger ATCC9142
- Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
- Current Trends in Herbal Medicines
- Awareness of selfie addiction among teenagers: A questionnaire-based study
- Design, Evaluation, Parameters and Marketed Products of transdermal patches: A Review
- Study the Effect of Phytochemical Constituents of Piper betel Leaves Extracts on Liver Disorders by in vivo Model
- Physiological changes in pregnancy
- Hypovolemic shock - A review
- Soxhlet Extraction of Neem seed (Azadirachta indica A. Juss) Using Hexane as a Solvent.
- GC-MS study and phytochemical profiling of Mimosa pudica Linn.
- A comparative study of pregabalin and gabapentin combinations in type 2 diabetic neuropathy patients
- Phytochemical Analysis of Cocos nucifera L
- Pharmacognostic Study Of Plant Euphorbia hirta L
- Impurity profile- A review
- Antibiofilm activity of temu kunci (Boesenbergia rotunda), an Indonesian medicinal plant extract, against root canal pathogens
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- Plant natural products: Their pharmaceutical potential against disease and drug resistant microbial pathogens
- Studies on antifungal properties of Talisadi Churna on human pathogens
- In-vitro anti-arthritic activity of Abutilon indicum (Linn.) Sweet
- Anti-oxidant activities of Biopolymeric Nanoparticles: Boon or Bane!
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Synthesis, and anti-cancer activity of some novel 3-(piperazin-1-yl)pyrazin-2-amine derivatives