Journal: Drug Invention Today

Article Id: JPRS-P'Col-00005451
Title: Study on the effect of piperine on gluconeogenic enzymes in the liver of type-2 diabetic rats
Category: Pharmacology
Section: Research Article
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    Aim: The study was designed to assess the effect of piperine on gluconeogenic enzymes in high-fat diet-induced type-2 diabetic rats. Experimental Design: Adult male Wistar rats were used and divided as Group I: Control; Group II: Type-2 diabetic rats; Group III: Type-2 diabetic rats treated with piperine (40 mg/kg body weight [b.wt]/day, orally for 30 days); and Group IV: Type-2 diabetic rats treated with metformin (50 mg/kg b.wt/day, orally for 30 days). After 30 days of treatment, animals were anesthetized; liver tissues were dissected out and used for the assessment of gluconeogenic enzymes such as glucose- 6-phosphatase and phosphoenolpyruvate carboxykinase (PEPCK) Results: In diabetic animals, glucose-6-phosphatase and PEPCK activity were significantly raised (P < 0.05) compared with control animals. Oral administration of the piperine reduced the activity of these enzymes (P < 0.05) to that of the control and standard drug metformin. Conclusion: The present study shows that piperine possesses antidiabetic activity by reducing gluconeogenic enzymes in the liver.

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    Author(s) Name:

    B. Sachin Aditya, J. Selvaraj*, V. Vishnu Priya, R. Gayathri

    Affiliation(s) Name:

    Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    B. Sachin Aditya, J. Selvaraj*, V. Vishnu Priya, R. Gayathri

    Title:Study on the effect of piperine on gluconeogenic enzymes in the liver of type-2 diabetic rats
    Journal:Drug Invention Today
    Vol(issue):13 (February )
    Year:2020
    Page No: (216-219)
  • Experimental Methods Keywords

    Methodology:Glucose-6-phosphatase, Phosphoenolpyruvate carboxykinase
    Research Materials:Piperine

Keywords

Glucose-6-phosphatase Phosphoenolpyruvate carboxykinase Piperine High-fat diet Type-2 diabetes

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