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Abstract

Rapidity in Drug development can be achieved by researchers on finding a mathematical link between bioavailability and dissolution testing which leads to the concept of in vitro - in vivo correlation (IVIVC). IVIVC is a mathematical model that can be used to estimate in vivo behaviour from its in vitro performance. Among all the five levels of correlation, Level A correlation is widely accepted by the regulatory agencies. Biopharmaceutical Classification System (BCS) explains the suitability of IVIVC. Dissolution method design plays a pivotal role in the estimation of correlations. Apparatus qualification and guidelines is other essential parameters in the study of IVIVC. Several factors such as first pass effect, stereochemistry, should be considered while developing IVIVC. In the present scenario, research is focussed in oral novel dosage forms where knowledge of IVIVC is of paramount importance. Applications of IVIVC ranges from drug and product development, their scale up and post approval changes. Hence, IVIVC should be considered as an important tool in drug development.

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	JPR Solutions

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