Journal: Journal of Pharmacy Research
Title: In vitro-In vivo Correlation (IVIVC): A Review
Category: Pharmaceutics
Section: Review Article
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Abstract
Rapidity in Drug development can be achieved by researchers on finding a mathematical link between bioavailability and dissolution testing which leads to the concept of in vitro - in vivo correlation (IVIVC). IVIVC is a mathematical model that can be used to estimate in vivo behaviour from its in vitro performance. Among all the five levels of correlation, Level A correlation is widely accepted by the regulatory agencies. Biopharmaceutical Classification System (BCS) explains the suitability of IVIVC. Dissolution method design plays a pivotal role in the estimation of correlations. Apparatus qualification and guidelines is other essential parameters in the study of IVIVC. Several factors such as first pass effect, stereochemistry, should be considered while developing IVIVC. In the present scenario, research is focussed in oral novel dosage forms where knowledge of IVIVC is of paramount importance. Applications of IVIVC ranges from drug and product development, their scale up and post approval changes. Hence, IVIVC should be considered as an important tool in drug development.
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About the authors and Affiliations
Author(s) Name: Amitava Ghosh1, Gopal Kumar Choudhury*2
Affiliation(s) Name: Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim-737136
Received on: 07-04-2009; Accepted on: 29-05-2009-
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Author: Amitava Ghosh1, Gopal Kumar Choudhury*2
Title: In vitro-In vivo Correlation (IVIVC): A Review Journal: Journal of Pharmacy Research Vol(issue): 2 (August) Year: 2009 Page No: (1255-1260) -
Experimental Methods Keywords
Methodology: IVIVC of Novel Dosage Forms Research Materials: In vitro-In vivo Correlation
Keywords
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