Journal: Journal of Pharmacy Research
Title: Formulation of bilayer tablet containing metoprolol succinate and amlodipine besylate as a model drug for antihypertensive therapy
Category: Pharmaceutics
Section: Research Article
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Abstract
The purpose of the present work was to develop an optimized bilayer tablet for antihypertension patients using Metoprolol succinate and Amlodipine besylate as a model drug candidate by optimization technique. A 32 factorial design was employed in formulating bilayer tablet with individual release layer i.e. sustained release layer and immediate release layer. The independent variables selected both cases HPMC(X1), Starch 1500 (X2) and SSG (X1), MCC (X2), respectively. Two dependent variables were considered: t50 (Y1), Q12 (Y2) and t50 (Y1), Q2 (Y2), respectively. The main effect and interaction terms were quantitatively evaluated using mathematical model. Bilayer tablets were evaluated for thickness, hardness, friability, drug content and in vitro dissolution studies. The drug release of Amlodipine besylate and Metoprolol succinate depicted non-fickian diffusion and Super Case II transport mechanism, respectively.
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About the authors and Affiliations
Author(s) Name: Atram SC*., Udavant YK., Salunke RJ., Neb GB., Shahi SR., Gulecha BS., Padalkar AN
Affiliation(s) Name: *Government College of Pharmacy, Aurangabad. 431005, India. (MS).
Received on: 27-04-2009; Accepted on: 09-06-2009-
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Author: Atram SC*., Udavant YK., Salunke RJ., Neb GB., Shahi SR., Gulecha BS., Padalkar AN
Title: Formulation of bilayer tablet containing metoprolol succinate and amlodipine besylate as a model drug for antihypertensive therapy Journal: Journal of Pharmacy Research Vol(issue): 2 (August) Year: 2009 Page No: (1335-1347) -
Experimental Methods Keywords
Methodology: Formulation of bilayer tablet, factorial design, non-fickian diffusion, super case II transport Research Materials: Metoprolol succinate and Amlodipine besylate
Keywords
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