Journal: Journal of Pharmacy Research
Title: Anti-nociceptive Activity of the Fruits of Swietenia macrophylla King.
Category: Pharmacology
Section: Research Article
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Abstract
Fruits of Swietenia macrophylla King (Meliaceae) are used in Malay folk medicine as pain killer. The antinociceptive effect of ethanol and aqueous extracts was assessed by oral administration in acetic acid induced writhing, tail immersion and hot plate tests in mice. The ethanol extract 200 mg/kg treated group reduces the number of writhing on animal model, showed powerful anti-nociceptive effect (P < 0.01). Also the significant (P < 0.01) analgesic activity of S. macrophylla ethanolic extract at the dose of 200 mg/kg was further confirmed by tail-flick response and hot-plate response (P < 0.01).S. macrophylla extract produce analgesic in chemical and thermal pain models through a mechanism partially linked to either lipooxygenase and/or cyclooxygenase via the arachidonic acid cascade and/or opioid receptors. Our results corroborate the analgesic effects of S.macrophylla, and confirm its traditional use for treating pain.
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About the authors and Affiliations
Author(s) Name: Amitava Das *, J.Anbu Jeba Sunilson, Rejitha Gopinath, Suraj Radhamani, Kiran Nilugal
Affiliation(s) Name: *School of Pharmacy, Masterskill University College of Health Sciences, 43200, Batu 9, Cheras, Selangor, Malaysia.
Received on: 27-04-2009; Accepted on: 29-07-2009-
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Author: Amitava Das *, J.Anbu Jeba Sunilson, Rejitha Gopinath, Suraj Radhamani, Kiran Nilugal
Title: Anti-nociceptive Activity of the Fruits of Swietenia macrophylla King. Journal: Journal of Pharmacy Research Vol(issue): 2 (September) Year: 2009 Page No: (1367-1369) -
Experimental Methods Keywords
Methodology: Anti-nociceptive Activity Research Materials: Swietenia macrophylla
Keywords
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