Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000608
Title: Development and evaluation of novel immediate release tablets of Metoclopramide HCl by direct compression using treated gellan gum as a disintegration-accelerating agent.
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    The aim of this study was to compare the disintegrants efficiency of the three superdisintegrants (Ac-Di-Sol, Polyplasdone XL and Explotab) and also to compare disintegrant properties and disintegrant efficiency of agar (AG) and gellan gum (GG) with treated agar (TAG) and treated gellan gum (TGG) by formulating metoclopramide HCl immediate release tablets by direct compression method. In the present investigation, we have attempted first time report on TGG as disintegrant. Disintegration efficiency of powder disintegrants compared by swelling & hydration capacity of disintegrants. While efficiency of disintegrants in tablets compared by various test like disintegration time, dissolution test, wetting time & maximal water uptake study of metoclopramide HCl immediate release tablets. The rapid disintegration observed for the TAG and TGG containing tablets due to high-porous structure of treated form of disintegrants which confirmed by photomicroscope study. Comparing three classes of superdisintegrants represented by Ac-Di-Sol, Polyplasdone XL and Explotab with AG, TAG, GG and TGG. The treated form of disintegrants (TAG, TGG) in which TAG was found to be more effective than TGG. The disintegration efficiency was found in following decreasing order Ac-Di-Sol, Explotab, Polyplasdone XL, TAG, TGG, AG and GG.

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  • About the authors and Affiliations

    Author(s) Name:

    B.G.Shiyani*, R.B.Dholakiya1, B.V.Akbari1, D.J.Lodhiya1, G.K.Ramani2

    Affiliation(s) Name:

    *, 1 Dept. of Pharmaceutics, Shree Dhanvantary Pharmacy College, Kim,Gujarat, India.
    2 Dept. of Pharmacology, Shree Dhanvantary Pharmacy College, Kim ,Gujarat, India.
    Shree Dhanvantary Pharmaceutical Analysis & Research Centre, Kim,Gujarat, India.


    Received on: 21-05-2009; Accepted on: 17-07-2009

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    Author:

    B.G.Shiyani*, R.B.Dholakiya1, B.V.Akbari1, D.J.Lodhiya1, G.K.Ramani2
    Title:Development and evaluation of novel immediate release tablets of Metoclopramide HCl by direct compression using treated gellan gum as a disintegration-accelerating agent.
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (September)
    Year:2009
    Page No: (1460-1464)

  • Experimental Methods Keywords

    Methodology:Development and evaluation of novel immediate release ,direct compression
    Research Materials:Metoclopramide HCl

Keywords

Immediate release tablet treated gellan gum disintegration.

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