Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000651
Title: New quantitative estimation of salicylic acid bulk sample using sodium saccharin as hydrotropic solubilizing agent
Category: Pharmaceutics
Section: Research Article
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    Solubilization of poorly water-soluble drugs has been a very important issue in screening studies of new chemical entities as well as in formulation research. A novel, safe and sensitive method of titrimetric estimation has been developed using 2 M sodium saccharin solution (an economic drug) as a hydrotropic solubilizing agent for the quantitative determination of salicylic acid in bulk, a sparingly water-soluble keratolytic drug. There was more than a 15-fold enhancement in aqueous solubility of salicylic acid in 2 M sodium saccharin solution as compared with the solubility in distilled water. The hydrotrope used in this work is freely soluble in water, non toxic and does not interfere in analysis. The results of analysis obtained by the proposed method are comparable with the results of analysis obtained by the Indian Pharmacopoeial method. The proposed method is new, simple, accurate and reproducible. Results of the analysis were validated statistically. Statistical data proved the accuracy, reproducibility and precision of the proposed method.

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    Author(s) Name:

    Rajesh Kumar Maheshwari*1, Mithun Singh Rajput2, Veena Nair2

    Affiliation(s) Name:

    1Department of Pharmacy, Shri G. S. Institute of Technology and Science, Indore - 452 003, India;2College of Pharmacy, IPS Academy, Indore - 452 012, India

    Received on: 20-09-2009; Revised on: 16-10-2009; Accepted on:17-12-2009

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    Author:

    Rajesh Kumar Maheshwari*1, Mithun Singh Rajput2, Veena Nair2

    Title:New quantitative estimation of salicylic acid bulk sample using sodium saccharin as hydrotropic solubilizing agent
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (January)
    Year:2010
    Page No: (6-8)
  • Experimental Methods Keywords

    Methodology:New quantitative estimation
    Research Materials: Salicylic acid

Keywords

Hydrotropy Salicylic acid Sodium saccharin Solubility enhancement.

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