Journal: Drug Invention Today
Title: Sedative and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn.---- vol1 issue 1 2009 [DIT]
Category: Pharmacological Screening
Section: Research Article
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Abstract
The central nervous system (CNS) depressant and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn (FH) were investigated on various animal models including pentobarbitone sleeping time and hole-board exploratory behaviour for sedation tests, and strychnine, picrotoxin, and pentylenetetrazole-induced convulsions in mice. FH (200 and 400mg/kg, p.o.), like chlorpromazine HCl (1mg/kg, i.m.), produced a dose-dependent prolongation of pentobarbitone sleeping time and suppression of exploratory behaviour. FH (200 and 400mg/kg) produced dose-dependent and significant (P < 0.05) increases in onset to clonic and tonic convulsions, and at 400mg/kg, showed complete protection against seizures induced by strychnine and picrotoxin but not with pentylenetetrazole. Acute oral toxicity test, up to 14 days, did not produce any visible signs of toxicity. These results suggest that potencially antiepileptic compounds are present in leaf extract of FH that deserve the study of their identity and mechanism of action.
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About the authors and Affiliations
Author(s) Name: Dhanasekaran.Sivaraman* and Palayan.Muralidaran
Affiliation(s) Name: *Department of Pharmacology and Toxicology,C.L.Baid Metha College of Pharmacy,Jyothi Nagar,Thoraipakkam,Chennai 97,Tamil Nadu,India.
*Corresponding author.
D.Sivaraman.
No: 51, Selva vinayagar Koil Street,
Perambur, Chennai-600011,
Tamil nadu,India
Tel.: + 91-9841575334
Fax.04425522874
E-mail: sivaramand83@gmail.comReceived on: 14-06-2009; Revised on: 01-07- 2009; Accepted on:10-09-2009
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Author: Dhanasekaran.Sivaraman* and Palayan.Muralidaran
Title: Sedative and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn.---- vol1 issue 1 2009 [DIT] Journal: Drug Invention Today Vol(issue): 1 (January 2009) Year: 2009 Page No: (23-27) -
Experimental Methods Keywords
Methodology: Pentobarbitone induced sleeping time.,Strychnine induced seizures, Picrotoxin-induced seizures,Pentylenetetrazole (PTZ)-induced seizures Research Materials: Ficus hispida Linn
Keywords
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