Article Id:JPRS-PS-000066 Title:Sedative and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn.---- vol1 issue 1 2009 [DIT] Category:Pharmacological Screening Section:Research Article
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The central nervous system (CNS) depressant and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn (FH) were investigated on various animal models including pentobarbitone sleeping time and hole-board exploratory behaviour for sedation tests, and strychnine, picrotoxin, and pentylenetetrazole-induced convulsions in mice. FH (200 and 400mg/kg, p.o.), like chlorpromazine HCl (1mg/kg, i.m.), produced a dose-dependent prolongation of pentobarbitone sleeping time and suppression of exploratory behaviour. FH (200 and 400mg/kg) produced dose-dependent and significant (P < 0.05) increases in onset to clonic and tonic convulsions, and at 400mg/kg, showed complete protection against seizures induced by strychnine and picrotoxin but not with pentylenetetrazole. Acute oral toxicity test, up to 14 days, did not produce any visible signs of toxicity. These results suggest that potencially antiepileptic compounds are present in leaf extract of FH that deserve the study of their identity and mechanism of action.