Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000664
Title: Azetidinone : A bioactive moiety
Category: Pharmaceutical Chemistry
Section: Review Article
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    2-Azetidinone is a β-lactam cyclic amide with four atoms in a ring. Traditionally β-lactam is a part of structure of broad spectrum antibiotic class of drugs – penicillins and cephalosporins .The ring ultimately is proven to be a generic descriptor for penicillin family. These molecules operate by forming a covalent adducts with membrane bound bacterial transpeptidases which are also known as penicillin binding proteins (PBPs), involved in the biosynthesis of cell walls.Cycloaddition of monochloracetylchloride with imine (Schiff base) result in formation of 2-azetidinone(â-lactam).Present work is an attempt to review chemistry, synthesis, spectral studies and applications of 2-azetidinones.

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    Author(s) Name:

    Mrunmayee Toraskar*1, Vithal Kulkarni2, Vilasrao Kadam1

    Affiliation(s) Name:

    1Bharati Vidyapeeth’s College of Pharmacy,Department of Pharmaceutical Chemistry,Sec-8,C.B.D. Belapur, Navi Mumbai 400614,India
    2poona College of Pharmacy, Erandwane, Pune-38,India

    Received on: 20-09-2009; Revised on: 14-10-2009; Accepted on:18-12-2009

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    Mrunmayee Toraskar*1, Vithal Kulkarni2, Vilasrao Kadam1

    Title:Azetidinone : A bioactive moiety
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (January)
    Page No: (169-173)
  • Experimental Methods Keywords

    Research Materials:2-Azetidinone


2-Azetidinone β-lactam Cyclic amide Antibacterial

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