Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000672
Title: Nanosuspension:A novel drug delivery system
Category: Pharmaceutics
Section: Review Article
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    During the last two decades, many modern technologies have been established in the pharmaceutical research and development area. The automation of the drug discovery process by technologies such as high-throughput screening, combinatorial chemistry, and computer- aided drug design is leading to a vast number of drug candidates possessing a very good efficacy. Unfortunately, many of these drug candidates are exhibiting poor aqueous solubility. The use of drug nanosuspension is an universal formulation approach to increase the therapeutic performance of these drugs in any route of administration. A nanosuspension is a submicron colloidal dispersion of drug particles which are stabilized by surfactants. Nanosuspension is defined as very finely dispersed solid drug particles in an aqueous vehicle for either oral and topical use or parenteral and pulmonary administration. The particle size distribution of the solid particles in nanosuspensions is usually less than one micron with an average particle size ranging between 200 and 600 nm. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion.This review article describes the physicochemical properties of drug nanosuspension, preparation methods and; its potential clinical advantages.

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  • About the authors and Affiliations

    Author(s) Name:

    Suryakanta Nayak*, Dibyasundar Panda1, Jagannath Sahoo2.

    Affiliation(s) Name:

    1Department of Pharmaceutics, Institute of Pharmacy & Technology, Salipur, Cuttack, Orissa-754202
    2Department of Pharmaceutics Royal College of Pharmacy & Health Sciences Andhapasara Road, Berhampur ,Ganjam, Orissa – 760002

    *Corresponding author.
    Suryakanta Nayak
    Department of Pharmaceutics, L.B.Rao Institute of Pharmaceutical Education and Research, B.D.Rao College Campus, Bethak Road, Khambhat, Anand, Gujarat-388620


    Received on: 23-09-2009; Revised on: 17-11-2009; Accepted on:05-01-2010

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    Author:

    Suryakanta Nayak*, Dibyasundar Panda1, Jagannath Sahoo2.

    Title:Nanosuspension:A novel drug delivery system
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (February)
    Year:2010
    Page No: (241-246)
  • Experimental Methods Keywords

    Methodology:Nanosuspension; Bioavailability enhancement
    Research Materials:Nanosuspension

Keywords

Nanosuspension; Bioavailability enhancement; Surfactants; Stabilizers.

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