Journal: Journal of Pharmacy Research
Title: Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
Category: Pharmaceutical Analysis
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
A simple, sensitive, reproducible and cost effective stability indicating UV Spectrophotometric method has been developed for quantitative determination of Sitagliptin Phosphate in bulk and pharmaceutical formulations. The UV spectrum was scanned between 200 to 400 nm and 267 nm was selected as maximum wavelength for absorption. Beer’s law was obeyed in the concentration range of 10-100 mg/ml. Good accuracy (99.87-100.45%), precision (%RSD 1.3147-1.2957) were found, the method was successfully applied to the pharmaceutical dosage form containing the above-mentioned drug without any interference by the excipients. The limit of detection and limit of quantification was found to be 0.16 ìg/ml & 0.45 ìg/ml respectively. Results of the analysis were validated as per ICH guidelines. Forced degradation studies includes the effect of temperature, oxidation, photolysis and susceptibility to hydrolysis across a wide range of pH values, were carried out according to the ICH requirements which can be used for the routine and quality control analysis of Sitagliptin Phosphate in raw material and pharmaceutical formulations.
Cite this article as: Parag Pathade , Md Imran ,Vinod Bairagi , Yogesh Ahire,Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form,Journal of Pharmacy Research 2011,4(3),871-873.
-
Abstract Audio
About the authors and Affiliations
Author(s) Name: Parag Pathade*1, Md Imran1, Vinod Bairagi 2 and Yogesh Ahire2
Affiliation(s) Name: *1Department of pharmaceutical analysis, KBHSSTs Institute of Pharmacy, Malegaon Dist Nasik Maharashtra India.
2Department of pharmacology,K.B.H.S.S.T’s institute of pharmacy, Malegaon-camp, Malegaon, Dist- Nasik, Maharashtra,India.*Corresponding author.
P. A. Pathade
Department of pharmaceutical analysis,
K.B.H.S.S.T’s institute of pharmacy,
Malegaon-camp, Malegaon,
Dist- Nasik, Maharashtra, India
Received on: 05-10-2010; Revised on: 14-12-2010; Accepted on:09-02-2011-
View Article File in pdf format.
Article File
-
View Article Citation Here.
49 View More -
How to Cite my Article.
Author: Parag Pathade*1, Md Imran1, Vinod Bairagi 2 and Yogesh Ahire2
Title: Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form Journal: Journal of Pharmacy Research Vol(issue): 4 (March) Year: 2011 Page No: (871-873) -
Experimental Methods Keywords
Methodology: Spectrometry, Stability Indicating, Validation. Research Materials: Sitagliptin Phosphate
Keywords
Our Services
- Analysis of Amino Acids By Paper Chromatography
- Advances in medical application of Swertia chirata plant extract in the treatment of diabetics: A brief review
- GC-MS study and phytochemical profiling of Mimosa pudica Linn.
- Phytochemical screening and in vitro anti-dandruff activities of bark extracts of neem (Azadirachta indica)
- Simultaneous estimation of Sitagliptin and Metformin hydrochloride in bulk and dosage form by UV spectrophotometry
- Review On: Fast Dissolving Tablet
- Orally Disintegrating Tablets: A Review
- Formulation of olmesartan medoxomil nanoparticulate drug delivery for enhancement of oral bioavailability by Ionic-Gelation Techniques
- Antidiabetic, antioxidant, and antibacterial potentials of endophytic fungi isolated from Cassia fistula
- Antimicrobial activity of seaweeds Gracillaria, Padina and Sargassum sps. on clinical and phytopathogensSubba Rangaiah G, Lakshmi P* and Manjula E
- Current Trends in Herbal Medicines
- Impurity profile- A review
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Effect of stress on academic performance of students in different streams
- A short review on smoker’s melanosis
- Effect of skipping breakfast and its impact on blood pressure
- Titanium dioxide nanoparticles as antibacterial agents against some pathogenic bacteria
- Awareness on various restraints in perceiving orthodontic treatment among the adolescent age group
- Evaluation of anticonvulsant activity of ethanolic extract of Nymphaea alba Linn. (white water lily) and its comparison with phenytoin sodium and sodium valproate in albino rats
- Citric acid production from cane molasses using submerged fermentation by Aspergillus niger ATCC9142
- Abrus precatorius Linnaeus: A Phytopharmacological Review
- Review on various techniques of solubility enhancement of poorly soluble drugs with special emphasis on solid dispersion
- Validation of Uv Spectrophotometric method for estimation of Levocetirizine Dihydrochloride in bulk and pharmaceutical formulation
- In vitro antioxidant property of siddha formulation, Irunelli karpam
- articipation of neuropeptide Y1 receptors in heart development regulation
- Variation in salivary pH and buffering capacity of saliva in normal and diabetes mellitus patients - A pilot study
- Awareness of effects of sleep deprivation among college students
- The effect of red betel leaves (Piper crocatum Ruiz and Pav.) on blood sugar and insulin expression levels in rat (Rattus norvegicus domesticus) models of diabetes mellitus
- Awareness on soil pollution among school students