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Abstract

Swallowing a pill is a major difficulty encountered in case of geriatric and pediatric patient which leads to poor patient compliance due to unpalatable taste of drug. To troubleshoot these problems a new dosage form known as fast-dissolving tablet (FDT), has been developed which rapidly disintegrate and dissolve in saliva. FDT are intended and designed to disintegrate and dissolve in saliva and then easily swallowed without need of water which is a major benefit over conventional dosage form. These dosage forms are also used to attain instant a higher concentration of drug in body for immediate actions. Fast dissolving tablets can be prepared by various conventional methods like direct compression, wet granulation, moulding, spray drying, freeze drying, and sublimation. In 1986, the first lyophilized fast-dissolving technology Zydis® was introduced by Cardinal formerly R. P. Scherer and after that there was a continuous growth in names , technologies & patented technology by different companies. Now a number of fast-dissolving formulations are in market like Claritin Reditab (Manufacturer R.P.Scherr,Inc.), Risperdal M-Tab (Manufacturer Janseen pharmaceutics.), Tempra Quicklets (Manufacturer Cima Labs,inc) and the technology is still improving. Present review focuses on the need of FDTs, pros and cons, drugs/marketed preparations, manufacturing process involved, evaluation of products and future trend.

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	JPR Solutions

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