Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000737
Title: Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent
Category: Pharmaceutical Chemistry
Section: Research Article
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    The present work was carried out to synthesize compounds with substituted quinazolinone semicarbazones at third position of the quinazoline nucleus and chemically modifying second position of quinazolinone to get the compounds with lesser side effects and more potent anticonvulsive agents. Although several new anticonvulsants are already in clinical use, some types of seizures are still not adequately treated with current therapy and have limitations, intolerable side effects. In response to these limitations, the development of new drugs to optimally manage seizures has been strongly advocated. Thus the search for new anticonvulsant drugs continues to be an active area of investigation in medicinal chemistry. The present study describes the synthesis of newer quinazoline derivatives and their anticonvulsant, antimicrobial activities. The newly synthesized compounds were evaluated intraperitoneally into the mice in the maximal electro shock (MES), subcutaneous strychnine threshold test (scSTY), using doses 30, 100, 300 mg/kg, and neurotoxicity screens, observation was carried out at two different time intervals. Almost all the synthesized analogue showed potent anticonvulsive activity. Some of the synthesized compounds were equipotent to the well known antiepileptic agent phenytoin. The synthesized compounds were found to potent anticonvulsant with less neurotoxicity.The synthesized compounds were also studied for antimicrobial potency. The antibacterial activity of synthesized quinazoline semicarbazones were characterized by antimicrobial screening against several gram-positive, gram negative bacteria. Antimicrobial screening for all the compounds exhibits characteristic microbial inhibition. A detailed study is in progress to modify the structural activity, and toxicological barriers for the enhanced pharmacological efficiency of synthetic antibiotics.

    Cite this article as: Ponnilavarasan Ilangovan1* , Swastika ganguly2 , Vijay pandi1, Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent, Journal of Pharmacy Research 2010, 3(4),703-706.

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    Author(s) Name:

    Ponnilavarasan Ilangovan1*, Swastika ganguly2, Vijay pandi1

    Affiliation(s) Name:

    1Department of Pharmaceutical chemistry,College of Pharmacy,Kovai Medical Center Research and Educational Trust,Coimbatore,641048,Tamilnadu, India.
    2Department of pharmacy, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India. 

    *Corresponding author.
    Ponnilavarasan Ilangovan 
    Department of Pharmaceutical chemistry, College of Pharmacy,
    Kovai Medical Center Research and Educational Trust,
    Coimbatore, 641048,Tamilnadu, India

    Received on: 20-11-2009; Revised on: 16-12-2009; Accepted on:15-02-2010

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    Ponnilavarasan Ilangovan1*, Swastika ganguly2, Vijay pandi1

    Title:Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (April)
    Page No: (703-706)
  • Experimental Methods Keywords

    Methodology:Anticonvulsant and Antimicrobial Agent
    Research Materials:Quinazolinone


Quinazolinone anticonvulsant Maximal electro shock Neurotoxicity antibacterial

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