Journal: Journal of Pharmacy Research
Title: Estimation of Thiocolchicoside And Ketoprofen in pharmaceutical dosage form by Spectrophotometric methods.
Category: Pharmaceutics
Section: Research Article
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Abstract
Two rapid, economical accurate and precise, methods have been developed for estimation of Thiocolchicoside and Ketoprofen in tablet dosage form. First method is first order derivative spectroscopy, wavelengths selected for quantitation were 233.0 nm for Thiocolchicoside (zero cross for Ketoprofen) and 243.0 nm for Ketoprofen (zero cross for Thiocolchicoside). Second method is Absorbance correction method in which absorbance is measured at two wavelengths 372.0 nm at which ketoprofen has no absorbance and 260.0 nm at which both the drugs have considerable absorbance. In first order derivative spectroscopy linearity for detector response was observed in the concentration range of 3-15 ìg/ml for Thiocolchicoside and 12-60 ìg/ml for Ketoprofen. In Absorbance correction method linearity for detector response was observed in the concentration range of 1-5 ìg/ml for Thiocolchicoside and 10-50 ìg/ml for Ketoprofen. The proposed methods were successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.
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About the authors and Affiliations
Author(s) Name: Sagar B.Wankhede*, Somnath S. Zambare and Sohan S. Chitlange
Affiliation(s) Name: Pad. Dr.D.Y.Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-18.
*Corresponding author.
Dr. Sagar B. Wankhede
Department of Pharmaceutical Chemistry,
Padmashree Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Rsearch
,Sant Tukaram Nagar, Pimpri,
Pune- 411018, Maharashtra, India.
Received on: 20-11-2009; Revised on: 16-12-2009; Accepted on:25-02-2010-
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Author: Sagar B.Wankhede*, Somnath S. Zambare and Sohan S. Chitlange
Title: Estimation of Thiocolchicoside And Ketoprofen in pharmaceutical dosage form by Spectrophotometric methods. Journal: Journal of Pharmacy Research Vol(issue): 3 (April) Year: 2010 Page No: (707-710) -
Experimental Methods Keywords
Methodology: First Order derivative spectroscopy; Absorbance correction method. Research Materials: Thiocolchicoside; Ketoprofen
Keywords
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