Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000747
Title: Review: Osmotic drug delivery systems current scenario
Category: Pharmaceutics
Section: Review Article
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    Osmotic drug delivery systems are new approach for a controlled release dosage form. Various patents available for osmotic drug delivery system like Rose-Nelson pump, Higuchi-leeper pump, higuchi-theeuwes pump, elementary osmotic pump etc. ODDS is useful for poorly soluble drug, for pulsatile drug release, zero order release. Varios techniques available for preparation of ODDS include push pull osmotic Pump, osmotic Brusting osmotic pump, liquid oral osmotic system, sandwiched osmotic tablets (SOTS), delayed delivery osmotic device, monolithic osmotic System and controlled porosity osmotic Pump. Osmotic ally controlled oral drug delivery systems utilize osmotic pressure for controlled delivery of active agent(s). Drug delivery from these systems, to a large extent, is independent of the physiological factors of the gastrointestinal tract. These systems can be utilized for systemic as well as targeted delivery of drugs. The release of drug(s) from osmotic systems is governed by various formulation factors such as solubility and osmotic pressure of the core component(s), size of the delivery orifice, and nature of the rate-controlling membrane. By optimizing formulation and processing factors, it is possible to develop osmotic systems to deliver drugs of diverse nature at a pre-programmed rate. In the present review, different types of oral osmotic systems, various aspects governing drug release from these systems, and critical formulation factors are discussed.

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  • About the authors and Affiliations

    Author(s) Name:

    R. S. Thakor*, F. D. Majmudar, J. K. Patel and G.C.Rajaput

    Affiliation(s) Name:

    Nootan Pharmacy College, Visnagar,S. P. Sahakar Dham,Near Kamana crossing,At & PO- Visnagar-384315,Gujarat,India

    *Corresponding author.
    Mr. Rashmin S. Thakor
    Nootan Pharmacy College,
    S. P. Sahakar Dham,
    Near Kamana crossing,
    At & PO- Visnagar-384315

    Received on: 27-12-2009; Revised on: 16-01-2010; Accepted on:17-03-2010

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    R. S. Thakor*, F. D. Majmudar, J. K. Patel and G.C.Rajaput

    Title:Review: Osmotic drug delivery systems current scenario
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (April)
    Page No: (771-775)
  • Experimental Methods Keywords

    Methodology:Osmotic drug delivery system, Zero order release, Pulsatile drug release
    Research Materials:Osmotic drug delivery systems


Osmotic drug delivery system Zero order release Pulsatile drug release

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