Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000749
Title: Formulation and Evaluation of Metformin Hydrochloride Sustained Release Matrix Tablets.
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    An attempt was to formulate the oral sustained release Metformin hydrochloride matrix tablets by using hydroxyl methyl cellulose polymer (HPMC) as rate controlling factor and to evaluate drug release parameters as per various release kinetic models. It is observed that the basic goal of therapy in the development of Metformin hydrochloride release dosage form is to increase bioavailability; reduce risk of hospitalization, deliver drug at a near constant rate for approximately 12 hrs, independent of food intact and gastrointestinal PH. The dry granulation technique was used to compress the tablet as powder showed the poor flowability; less cohesiveness during direct compression and due to moisture sensitivity and tendency to hydrolyte, wet granulation techniques was not selected for the present work. Dry granulation improves the flow of the powder and reduces the use excipients. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity, drug content etc. and showed satisfactory results. The tablets were subjected to thickness, weight variation test, drug content, hardness, friability and in vitro release studies. The in vitro dissolution study was carried out for 12 hours using PH 4.0, 6.8 Phosphate buffer & pH 1.2 buffer in phosphate buffer as dissolution media. All the tablet formulations showed acceptable pharmacotechnical properties and complied with pharmacopoeial specifications. The mechanism of drug release form matrix tablet is govorenered by diffusion and as the drug is so highly soluble. However, when considering in-vivo behavior of this system, the erosion rate will be more important.

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  • About the authors and Affiliations

    Author(s) Name:

    *Saptarshi Dutta1, Dr. Srinivas Rao2.

    Affiliation(s) Name:

    1Department of Pharmaceutics, L.B.R.I.P.E.R., Khambhat, Anand, Gujarat-388620
    2JKKMMRF’S-Annai JKK Sampoorani Ammal college of Pharmacy, Komarapalayam, Taminnadu.

    *Corresponding author.
    Saptarshi Dutta
    1Department of Pharmaceutics, L.B.R.I.P.E.R.,
    Khambhat, Anand, Gujarat-388620


    Received on: 20-09-2009; Revised on: 16-10-2009; Accepted on:11-02-2010

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    Author:

    *Saptarshi Dutta1, Dr. Srinivas Rao2.

    Title:Formulation and Evaluation of Metformin Hydrochloride Sustained Release Matrix Tablets.
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (April)
    Year:2010
    Page No: (781-784)
  • Experimental Methods Keywords

    Methodology:Formulation and Evaluation,Sustained release, Dry granulation.
    Research Materials:Metformin HCl

Keywords

Metformin HCl Sustained release HPMC Dry granulation.

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