Journal: Journal of Pharmacy Research
Title: In vitro anti-Candida activity of Calotropis gigantea.
Category: Pharmaceutical Biotechnology
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
The aim of this study is to screen leaves of Calotropis gigantea for the anti-Candida properties against four clinical isolates of Candida. Aqueous, methanol, ethanol and petroleum ether extracts of the leaves of Calotropis gigantea were screened against clinical isolate of Candida albicans, C. parapsilosis, C. tropicalis and C. krusei. The in vitro anti-Candida assay was performed by agar well diffusion method in potato dextrose agar (PDA). Minimal inhibitory concentration (MIC) test was performed by modified agar well diffusion assay in PDA. The inhibitory effect of aqueous extract on all four tested Candida species was significantly higher than the methanol, ethanol and petroleum ether extracts. Aqueous extract showed low MIC values against C. tropicalis (125 μg/ml), C. krusei (250 μg/ml) and C. albicans (500 ìg/ml), followed by the methanol extract against C. tropicalis, C. krusei (500 μg/ml) and petroleum ether extract against C. tropicalis (500 μg/ml). The results prove Calotropis gigantea as a potent source of natural anti-Candida compounds.
Cite this article :Gaurav Kumar, Loganathan Karthik and Kokati Venkata Bhaskara Rao,In vitro anti-Candida activity of Calotropis gigantea,Journal of Pharmacy Research 2010, 3(3),539-542.
.Journal of Pharmacy Research 2010, 3(3),539-542 -
Abstract Audio
About the authors and Affiliations
Author(s) Name: Gaurav Kumar, Loganathan Karthik and Kokati Venkata Bhaskara Rao*.
Affiliation(s) Name: *Environmental Biotechnology Division, School of Bioscience and Technology, VIT University, Vellore, TN - 632 014, India
*Corresponding author.
Dr. Kokati Venkata Bhaskara Rao
Assistant Professor (Senior), Environmental Biotechnology Division
School of Bioscience and Technology
VIT University, Vellore, TN - 632 014, India
Received on: 17-11-2009; Revised on: 19-12-2009; Accepted on:08-02-2010-
View Article File in pdf format.
Article File
-
View Article Citation Here.
47 View More -
How to Cite my Article.
Author: Gaurav Kumar, Loganathan Karthik and Kokati Venkata Bhaskara Rao*.
Title: In vitro anti-Candida activity of Calotropis gigantea. Journal: Journal of Pharmacy Research Vol(issue): 3 (March) Year: 2010 Page No: (539-542) -
Experimental Methods Keywords
Methodology: minimal inhibitory concentration; well diffusion method. Research Materials: Calotropis gigantea
Keywords
Our Services
- Analysis of Amino Acids By Paper Chromatography
- Advances in medical application of Swertia chirata plant extract in the treatment of diabetics: A brief review
- GC-MS study and phytochemical profiling of Mimosa pudica Linn.
- Phytochemical screening and in vitro anti-dandruff activities of bark extracts of neem (Azadirachta indica)
- Simultaneous estimation of Sitagliptin and Metformin hydrochloride in bulk and dosage form by UV spectrophotometry
- Review On: Fast Dissolving Tablet
- Orally Disintegrating Tablets: A Review
- Formulation of olmesartan medoxomil nanoparticulate drug delivery for enhancement of oral bioavailability by Ionic-Gelation Techniques
- Antidiabetic, antioxidant, and antibacterial potentials of endophytic fungi isolated from Cassia fistula
- Antimicrobial activity of seaweeds Gracillaria, Padina and Sargassum sps. on clinical and phytopathogensSubba Rangaiah G, Lakshmi P* and Manjula E
- Current Trends in Herbal Medicines
- Impurity profile- A review
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Effect of stress on academic performance of students in different streams
- A short review on smoker’s melanosis
- Effect of skipping breakfast and its impact on blood pressure
- Titanium dioxide nanoparticles as antibacterial agents against some pathogenic bacteria
- Awareness on various restraints in perceiving orthodontic treatment among the adolescent age group
- Evaluation of anticonvulsant activity of ethanolic extract of Nymphaea alba Linn. (white water lily) and its comparison with phenytoin sodium and sodium valproate in albino rats
- Citric acid production from cane molasses using submerged fermentation by Aspergillus niger ATCC9142
- Abrus precatorius Linnaeus: A Phytopharmacological Review
- Review on various techniques of solubility enhancement of poorly soluble drugs with special emphasis on solid dispersion
- Validation of Uv Spectrophotometric method for estimation of Levocetirizine Dihydrochloride in bulk and pharmaceutical formulation
- In vitro antioxidant property of siddha formulation, Irunelli karpam
- articipation of neuropeptide Y1 receptors in heart development regulation
- Variation in salivary pH and buffering capacity of saliva in normal and diabetes mellitus patients - A pilot study
- Awareness of effects of sleep deprivation among college students
- The effect of red betel leaves (Piper crocatum Ruiz and Pav.) on blood sugar and insulin expression levels in rat (Rattus norvegicus domesticus) models of diabetes mellitus
- Awareness on soil pollution among school students