Journal: Journal of Pharmacy Research
Title: Evaluation of wound healing and antimicrobial activity of Lannea coromandelica (Houtt) Merr
Category: Pharmacology
Section: Research Article
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Abstract
Ethanol and acetone extracts of Lannea coromandelica (Houtt) merr (Anacardiaceae) barks in the form of simple ointments screened for wound-healing activity by incision and excision wound on male Wister rats. In excision wound model, more than 95% wound healing was recorded in treated groups by 16 days of post surgery, whereas only 85.40% was observed in control group. Significant (P<0.01) epithelialization was observed in the groups treated with both ethanol and acetone extract ointments. In incision wound model higher breaking strength were observed 82.43%, 63.77% in ethanol and acetone extracts treated groups respectively suggested higher collagen re-deposition than the control group. Framycetin sulphate (1%) was used as standard in both incision and excision wound models. Finally, histopathological studies confirmed the wound healing properties. The results shown that Lannea coromandelica extract has potent wound healing activity by in terms of significant wound contraction and increased tensile strength. Since wound healing is severely influenced by microbial infection, this study was extended to evaluate antimicrobial activity apart from wound healing activity. The antimicrobial activity was determined by disc diffusion method.
Cite this article as: Sathish R, Mohd HA, Natarajan K, Lalitha KG. Evaluation of wound healing and antimicrobial activity of Lannea coromandelica (Houtt) Merrill. J Pharm Res 2010;3:1225-1228.
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About the authors and Affiliations
Author(s) Name: R. Sathish1, Mohd hasib Ahmed1, K. Natarajan2, K.G. Lalitha3
Affiliation(s) Name: 1Department of Pharmacology, Ultra College of Pharmacy, Madurai, 2 Department of Pharmaceutical biotechnology, Ultra college of Pharmacy, Madurai, 3Department of Pharmaceutical Chemistry, Ultra college of Pharmacy, Madurai, TamilNadu, India.
*Corresponding author.
R. Sathish, M.Pharm,
Asst. Professor, Department of Pharmacology,
Ultra College of Pharmacy,
Madurai – 625020, TamilNadu, India
Received on: 15-03-2010; Revised on: 14-04-2010; Accepted on:19-05-2010-
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Author: R. Sathish1, Mohd hasib Ahmed1, K. Natarajan2, K.G. Lalitha3
Title: Evaluation of wound healing and antimicrobial activity of Lannea coromandelica (Houtt) Merr Journal: Journal of Pharmacy Research Vol(issue): 3 (June) Year: 2010 Page No: (1225-1228) -
Experimental Methods Keywords
Methodology: Wound healing,Tensile strength; Antimicrobial activity. Research Materials: Lannea coromandelica
Keywords
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