Journal: Journal of Pharmacy Research
Title: Anti-inflammatory and anti-nociceptive activity of Rhododendron arboreum
Category: Pharmacology
Section: Research Article
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Abstract
In the present study the ethyl acetate extract of Rhododendron arboreum (Family: Ericaceae) was investigated for its anti-inflammatory and anti-nociceptive potential in animal models.Oral administration of Rhododendron arboreum extract (EERA) (100, 200 and 400 mg/kg) exhibited dose dependent and significant anti-inflammatory activity in arachidonic induced hind paw edema (p<0.01), cotton pellet granuloma model of inflammation (p<0.01) and Freund’s adjuvant-induced paw arthritis (p<0.01). A significant (p<0.05) anti-nociceptive activity was evidenced in mice, protection in acetic acid-induced writhing. EERA at the dose levels of 100,200 and 400 mg/kg exhibited significant (p<0.001) resistance against analgesymeter induced pain in mice. The hot plate reaction time was increased at a dose of 100, 200 and 400 mg/kg significantly (p<0.001).The present study justifies the anti-inflammatory and anti-nociceptive potential of Rhododendron arboreum.
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About the authors and Affiliations
Author(s) Name: Neeraj Verma1*, Anil Pratap Singh3, G. Amresh1, P. K. Sahu2, Ch. V. Rao3
Affiliation(s) Name: 1 Goel Institute of Pharmacy & Sciences, Faizabad Road (Near Indira Canal) Lucknow 227105, Uttar Pradesh, India
2 School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Kalinga Nagar, Ghatikia, Bhubaneswar 751003, Orissa, India
3 Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute (Council of Scientific and Industrial Research), Rana Pratap Marg, P.O. Box No. 436, Lucknow 226001,Uttar Pradesh, India*Corresponding author.
Neeraj Verma
Goel Institute of Pharmacy & Sciences,
Faizabad Road (Near Indira Canal)
Lucknow 227105, Uttar Pradesh, India
Received on: 20-02-2010; Revised on: 16-03-2010; Accepted on:15-04-2010-
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Author: Neeraj Verma1*, Anil Pratap Singh3, G. Amresh1, P. K. Sahu2, Ch. V. Rao3
Title: Anti-inflammatory and anti-nociceptive activity of Rhododendron arboreum Journal: Journal of Pharmacy Research Vol(issue): 3 (June) Year: 2010 Page No: (1376-1380) -
Experimental Methods Keywords
Methodology: Anti-inflammatory, Anti-nociceptive. Research Materials: Rhododendron arboreum (Ericaceae)
Keywords
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