Journal: Journal of Pharmacy Research
Title: Pharmacological evaluation of ethanolic extracts of the plant Alternanthera sessilis against temperature regulation
Category: Pharmacology
Section: Research Article
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Abstract
Purpose: The antipyretic activity of the 90 % ethanol extract of the aerial parts of Alternanthera sessilis. (Amaranthaceae) was investigated in other to verify its claimed ethno medicinal use in the treatment of fever.Method: The antipyretic activity of Alternanthera sessilis extract (ASE) was investigated for its, potential on normal body temperature and yeast-induced pyrexia in albino rats. Results: The ASE at doses of 200, and 400 mg/kgBW p.o., showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect also extended upto 4 h after the drug administration. The anti-pyretic effect of ASE was comparable to that of paracetamol (150 mg/kg p.o.,), a standard anti-pyretic agent. Conclusion: Based on the results of the present study it can be concluded that the extract of A. sessilis has potential antipyretic activity. The activity is in dose dependent manner.Consequently our present study gives a scientific ground to the traditional uses of the plant A.sessilis
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About the authors and Affiliations
Author(s) Name: Praveen Nayak1, * Shweta Nayak1, DM Kar2, Prabhat Das1
Affiliation(s) Name: 1GRY Institute of Pharmacy, Vidya Vihar, Borawan, Khargone, MP- 451228.
2SPS, SOA University Bhubaneswar, Orissa*Corresponding author.
Praveen Singh Nayak
GRY Institute of Pharmacy, Vidya Vihar, Borawan, Khargone, MP- 451228
Received on: 11-03-2010; Revised on: 19-04-2010; Accepted on:25-05-2010-
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Author: Praveen Nayak1, * Shweta Nayak1, DM Kar2, Prabhat Das1
Title: Pharmacological evaluation of ethanolic extracts of the plant Alternanthera sessilis against temperature regulation Journal: Journal of Pharmacy Research Vol(issue): 3 (June) Year: 2010 Page No: (1381-1383) -
Experimental Methods Keywords
Methodology: Pharmacological evaluation Research Materials: Alternanthera sessilis, yeast-induced pyrexia, antipyretic activity
Keywords
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