Journal: Drug Invention Today
Title: Evaluation of the Hypoglycemic, Hypolipidemic and Antioxidant Effects of Methanolic Extract of “Ata-Ofa” Polyherbal Tea (APolyherbal) in Alloxan-Induced Diabetic Rats
Category: Pharmacological Screening
Section: Research Article
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Abstract
Methanolic extract of “Ata-Ofa Polyherbal tea” (A-Polyherbal) was evaluated for hypoglycemic, hypolipidemic and antioxidant effects in alloxan-induced diabetic rats. Compared to the untreated diabetic rats, administration of methanolic extract of A-Polyherbal at 50mg/kg dose for 7 days caused a statistically significant (P < 0.05) percentage reduction in fasting blood glucose level (55.43±3.50%), significantly boosted the activities of superoxide dismutases and catalases, HDLcholesterol, packed cell volume and hemoglobin, and significantly (P < 0.05) reduced the levels of thiobarbituric reactive substances (TBARS), total cholesterol, total bilirubin, conjugated bilirubin, in alloxan-induced diabetic rats. These results strongly demonstrate that “Ata-Ofa Polyherbal tea” (A-Polyherbal) has strong potential in the alleviation and management of diabetes and related complications, including hyperglycemia, oxidative stress, development of micro and macro vascular diabetic complications arising from elevated plasma lipids and decreased levels of antioxidant defense systems, as well as reduced erythrocyte survival rate.
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About the authors and Affiliations
Author(s) Name: Sunday E Atawodi*
Affiliation(s) Name: Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
Corresponding Author:
Sunday E Atawodi, Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
Received 27-06-2011; Accepted 24-10-2011-
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Author: Sunday E Atawodi*
Title: Evaluation of the Hypoglycemic, Hypolipidemic and Antioxidant Effects of Methanolic Extract of “Ata-Ofa” Polyherbal Tea (APolyherbal) in Alloxan-Induced Diabetic Rats Journal: Drug Invention Today Vol(issue): 3 (November) Year: 2011 Page No: (270-276) -
Experimental Methods Keywords
Methodology: Hypoglycemic effect; Antioxidant effect, Hypolipidemic effect; alloxandiabetes; anti-diabetic effect Research Materials: Ata-Ofa Polyherbal tea
Keywords
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