Journal: Drug Invention Today
Title: Recent advances in self emulsifying drug delivery system - A review
Category: Drug (Discovery/Development)
Section: Review Article
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Abstract
Self-emulsifying drug delivery systems (SEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. From time to time many workers have claimed various rational applications of Self-emulsifying formulation for enhancing bioavailability and site-specific targeting of highly lipophilic drugs. SEDDS is ideally an isotropic mixture of oils and surfactants and sometimes co solvents. The multi-component delivery systems have optimized by evaluating their ability to self-emulsify when introduced to an aqueous medium under gentle agitation, and by determination of particle size of the resulting emulsion. Upon per oral administration, these systems form fine (micro) emulsions in the gastrointestinal tract (GIT) with mild agitation provided by gastric mobility. These articles
give an overview of the recent advances in the development of SEDDS and the dosage forms along with the associated problems and the possible future research directions in this field. -
Abstract Audio
About the authors and Affiliations
Author(s) Name: A Pathak*1, V Jain1, AK Nagariya1, R Singh1, S Nayak2, P Bansal3, V Gupta3, S Kumar3, Harinder Singh4
Affiliation(s) Name: 1School of Pharmaceutical Sciences, Meerut, India
2Bansal College of Pharmacy, Bhopal, India
3National Institute of Ayurvedic Pharmaceutical Research, Patiala, India
4Goverment Medical College, Patiala, India*Corresponding author.
Amresh Pathak,
School of Pharmaceutical Sciences, Meerut, India
Received on: 20-05-2009; Revised on: 21-06- 2009; Accepted on:15-07-2009-
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Author: A Pathak*1, V Jain1, AK Nagariya1, R Singh1, S Nayak2, P Bansal3, V Gupta3, S Kumar3, Harinder Singh4
Title: Recent advances in self emulsifying drug delivery system - A review Journal: Drug Invention Today Vol(issue): 2 (February) Year: 2010 Page No: (123-129) -
Experimental Methods Keywords
Methodology: Self-emulsifying drug delivery systems (SEDDS) Research Materials: Synthetic drugs
Keywords
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