Journal: Drug Invention Today
Title: Efficacy of Cynodon dactylon for immunomodulatory activity
Category: Pharmacological Screening
Section: Research Article
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Abstract
Cynodon dactylon (Poaceae) commonly known as arugampul, is a perennial grass, forming thick mats by means of stolons and rhizomes. It is bitter, sharp, hot taste, good odour, laxative, brain and heart tonic, emetic, expectorant, carminative and useful against pains, inflammation and tooth ache. In the present study an attempt has been made to evaluate Cynodon dactylon protein fraction immunomodulatory activity. Cynodon dactylon protein (Cdpf) was administered intraperitonealy at doses of ED50 to healthy Swiss albino mice. Assessment of immunomodulatory activity was carried out by testing the humoral (antibody titre) and cellular (foot pad swelling) immune responses to the antigenic challenges with sheep RBCs and by neutrophil adhesion test. Intraperitonealy administered Cdpf showed a significant increase of test parameters Viz., neutrophil test, Haemagglutinating Antibody Titre (HAT) and Delayed Type Hypersensitivity (DTH) response. In mice immunized with sheep RBC, Cdpf enhanced the humoral antibody response to the antigen and significantly potentiated the cellular immunity by facilitating the food pad thickness response to sheep RBC in sensitized mice. There was increase in immunomodulation, there was significant improvement compared to control group and differences were statistically significant in Cdpf, therefore Cynodon dactylon protein fraction promises strong utility in clinical practice as an effective immunostimulant.
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About the authors and Affiliations
Author(s) Name: R.Santhi*and S.Annapoorani1
Affiliation(s) Name: *Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women, Elayampalayam, Tiruchengode – 637 205, Tamilnadu.
1 Department of Biochemistry, Avinashilingam University, Coimbatore – 641 043, Tamilnadu.*Corresponding author.
R.Santhi
Department of Biochemistry, Vivekanandha College of Arts and Sciences for
Women, Elayampalayam, Tiruchengode – 637 205, Tamilnadu.
Received on: 26-11-2009; Revised on: 14-12- 2009; Accepted on:18-01-2010-
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Author: R.Santhi*and S.Annapoorani1
Title: Efficacy of Cynodon dactylon for immunomodulatory activity Journal: Drug Invention Today Vol(issue): 2 (February) Year: 2010 Page No: (112-114) -
Experimental Methods Keywords
Methodology: Immunomodulatory activity Research Materials: Cynodon dactylon
Keywords
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