Article Id:JPRS-PS-0000921 Title:Efficacy of Cynodon dactylon for immunomodulatory activity Category:Pharmacological Screening Section:Research Article
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Abstract
Cynodon dactylon (Poaceae) commonly known as arugampul, is a perennial grass, forming thick mats by means of stolons and rhizomes. It is bitter, sharp, hot taste, good odour, laxative, brain and heart tonic, emetic, expectorant, carminative and useful against pains, inflammation and tooth ache. In the present study an attempt has been made to evaluate Cynodon dactylon protein fraction immunomodulatory activity. Cynodon dactylon protein (Cdpf) was administered intraperitonealy at doses of ED50 to healthy Swiss albino mice. Assessment of immunomodulatory activity was carried out by testing the humoral (antibody titre) and cellular (foot pad swelling) immune responses to the antigenic challenges with sheep RBCs and by neutrophil adhesion test. Intraperitonealy administered Cdpf showed a significant increase of test parameters Viz., neutrophil test, Haemagglutinating Antibody Titre (HAT) and Delayed Type Hypersensitivity (DTH) response. In mice immunized with sheep RBC, Cdpf enhanced the humoral antibody response to the antigen and significantly potentiated the cellular immunity by facilitating the food pad thickness response to sheep RBC in sensitized mice. There was increase in immunomodulation, there was significant improvement compared to control group and differences were statistically significant in Cdpf, therefore Cynodon dactylon protein fraction promises strong utility in clinical practice as an effective immunostimulant.
*Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women, Elayampalayam, Tiruchengode – 637 205, Tamilnadu. 1 Department of Biochemistry, Avinashilingam University, Coimbatore – 641 043, Tamilnadu.
*Corresponding author. R.Santhi Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women, Elayampalayam, Tiruchengode – 637 205, Tamilnadu.
Received on: 26-11-2009; Revised on: 14-12- 2009; Accepted on:18-01-2010
Efficacy of Cynodon dactylon for immunomodulatory activity
Journal:
Drug Invention Today
Vol(issue):
2 (February)
Year:
2010
Page No:
(112-114)
Experimental Methods Keywords
Methodology:
Immunomodulatory activity
Research Materials:
Cynodon dactylon
Keywords
Cdpf (Cynodon dactylon protein fraction) HAT (Haemagglutinating Antibody Titre) DTH (Delayed Type Hypersensitivity) NI (Neutrophil Index) CMI (Cell mediated Immunity)