Journal: Drug Invention Today

Article Id: JPRS-PS-0000921
Title: Efficacy of Cynodon dactylon for immunomodulatory activity
Category: Pharmacological Screening
Section: Research Article
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  • Abstract

    Cynodon dactylon (Poaceae) commonly known as arugampul, is a perennial grass, forming thick mats by means of stolons and rhizomes. It is bitter, sharp, hot taste, good odour, laxative, brain and heart tonic, emetic, expectorant, carminative and useful against pains, inflammation and tooth ache. In the present study an attempt has been made to evaluate Cynodon dactylon protein fraction immunomodulatory activity. Cynodon dactylon protein (Cdpf) was administered intraperitonealy at doses of ED50 to healthy Swiss albino mice. Assessment of immunomodulatory activity was carried out by testing the humoral (antibody titre) and cellular (foot pad swelling) immune responses to the antigenic challenges with sheep RBCs and by neutrophil adhesion test. Intraperitonealy administered Cdpf showed a significant increase of test parameters Viz., neutrophil test, Haemagglutinating Antibody Titre (HAT) and Delayed Type Hypersensitivity (DTH) response. In mice immunized with sheep RBC, Cdpf enhanced the humoral antibody response to the antigen and significantly potentiated the cellular immunity by facilitating the food pad thickness response to sheep RBC in sensitized mice. There was increase in immunomodulation, there was significant improvement compared to control group and differences were statistically significant in Cdpf, therefore Cynodon dactylon protein fraction promises strong utility in clinical practice as an effective immunostimulant.

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  • About the authors and Affiliations

    Author(s) Name:

    R.Santhi*and S.Annapoorani1

    Affiliation(s) Name:

    *Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women, Elayampalayam, Tiruchengode – 637 205, Tamilnadu.
    1 Department of Biochemistry, Avinashilingam University, Coimbatore – 641 043, Tamilnadu.

    *Corresponding author.
    R.Santhi
    Department of Biochemistry, Vivekanandha College of Arts and Sciences for
    Women, Elayampalayam, Tiruchengode – 637 205, Tamilnadu.


    Received on: 26-11-2009; Revised on: 14-12- 2009; Accepted on:18-01-2010

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    Author:

    R.Santhi*and S.Annapoorani1
    Title:Efficacy of Cynodon dactylon for immunomodulatory activity
    Journal:Drug Invention Today
    Vol(issue):2 (February)
    Year:2010
    Page No: (112-114)

  • Experimental Methods Keywords

    Methodology:Immunomodulatory activity
    Research Materials:Cynodon dactylon

Keywords

Cdpf (Cynodon dactylon protein fraction) HAT (Haemagglutinating Antibody Titre) DTH (Delayed Type Hypersensitivity) NI (Neutrophil Index) CMI (Cell mediated Immunity)

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