Journal: Drug Invention Today

Article Id: JPRS-PS-0000929
Title: Anticonvulsant Activity of whole parts of Sphaeranthus indicus Linn. Extract in Experimental Mice
Category: Pharmacological Screening
Section: Research Article
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    Purpose: The aim of the present study was to investigate anticonvulsant effect of the Petroleum ether, Benzene, Chloroform, Ethanol and triple distilled water extract of whole parts of the plant of the Sphaeranthus indicus Linn. (Compositae) on electrically and chemically induced seizures.Methods: The Petroleum ether, Benzene, Chloroform, Ethanol and water extract of the whole parts of the plant of S.indicus (200 and 400 mg/kg, i.p.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and pentylenetetrazole-, picrotoxin-, bicuculline- and N-methyl-dl-aspartic acid-induced seizures in mice. The latency of tonic convulsions and the number of animals protected from tonic convulsions were noted. Results: Ethanol extract (200- 400 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES). However, only 200 and 400mg/kg of the extract conferred protection (25 and 50%, respectively) on the mice. The same doses also protected animals from pentylenetetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures produced by picrotoxin and N-methyl-dl-aspartic acid. The extract had no effect on bicuculline-induced seizures. The aqueous extract (400mg/kg) significantly reduced the latency, but did not alter the incidence of seizures elicited by maximal electroshock to any significant extent. Conclusion: The data suggest that the ethanolic root extract of S.indicus may produce its anticonvulsant effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by pentylenetetrazole and picrotoxin.

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    Author(s) Name:

    Bikash Kumar Nanda1*, Jyotirmoyee Jena2, Bhabagrahi Rath2, Biswaranjan Behera1

    Affiliation(s) Name:

    1* Dadhichi College of Pharmacy, Sundergram, Cuttack-754002, Orissa.
    2 Department of Pharmacology, V.S.S Medical College, Burla, Sambalpur, Orissa.

    *Corresponding author.
    Bikash Kumar Nanda
    Assistant Professor
    Dadhichi College of Pharmacy
    Sundergram, Cuttack-754002,
    Orissa


    Received on: 24-11-2009; Revised on: 18-12- 2009; Accepted on:16-02-2010

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    Author:

    Bikash Kumar Nanda1*, Jyotirmoyee Jena2, Bhabagrahi Rath2, Biswaranjan Behera1

    Title:Anticonvulsant Activity of whole parts of Sphaeranthus indicus Linn. Extract in Experimental Mice
    Journal:Drug Invention Today
    Vol(issue):2 (March)
    Year:2010
    Page No: (202-206)
  • Experimental Methods Keywords

    Methodology:Anticonvulsant Activity
    Research Materials:Sphaeranthus indicus

Keywords

Sphaeranthus indicus Anticonvulsant activity Electroshock & Chemical induced Seizures Mice.

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