Journal: Drug Invention Today

Article Id: JPRS-BSN-0000930
Title: In vivo and in silico studies with the latex of the milk weed- Calotropis procera (Ait) R.Br
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
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    The toxic milk weed-Calotropis procera has gained popularity in scientific research with the increased awareness of its uses in different areas of applications. Insufficient knowledge about the molecular mechanism of this plant’s latex in vivo limits the scope of their application and hinders the effort to design new drugs from Calotropis sp. To study first pass metabolic effect in vivo,plasma from Wistar albino rats (after dosing with aqueous extract of dried latex (DL) of C. procera at 300mg/kg bodyweight either alone or in combination with 10% Fructose in drinking water), were analyzed with electrospray tandem mass spectrometry coupled to liquid chromatography (ESI-LC-MS/MS) to obtain metabolite changes by global profiling of low molecular weight metabolites. To provide insight into assessing new initiatives required to manipulate human physiology in cases of accidental exposure to latex, in this study, compounds of Calotropis latex were docked with receptors of Renin Angiotensin System (RAS) and the binding residues were identified. This study would facilitate our understanding of the role of these elicited low molecular metabolites in disease and toxicity and the identified binding amino acid residues would assist in drug development from Calotropis compounds.

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    Author(s) Name:

    R.G.Hemalatha 1 and *Dr.E. Padmini 2

    Affiliation(s) Name:

    1 Research Scholar, Mother Teresa Women’s University, Kodaikanal- 624 102
    *2 Associate Professor, Department of Biochemistry, Bharathi Women’s College, Chennai-600 108.

    *Corresponding author.
    Dr. E. Padmini,
    Department of Biochemistry,
    Bharathi Women’s College,
    Chennai-600 108, Tamilnadu, India


    Received on: 20-12-2009; Revised on: 21-01- 2010; Accepted on:15-02-2010

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    Author:

    R.G.Hemalatha 1 and *Dr.E. Padmini 2

    Title:In vivo and in silico studies with the latex of the milk weed- Calotropis procera (Ait) R.Br
    Journal:Drug Invention Today
    Vol(issue):2 (March)
    Year:2010
    Page No: (207-211)
  • Experimental Methods Keywords

    Methodology:In vivo and in silico studies
    Research Materials:Calotropis procera (Ait) R.Br

Keywords

Renin Angiotensin System Dried Latex In silico Docking Metabolite Profiling Toxicity

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