Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000095
Title: Preparation and evaluation of Venlafaxine hydrochloride Microspheres by Ionotropic Gelation method
Category: Pharmaceutics
Section: Research Article
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    Introduction: Venlafaxine hydrochloride (VHL) an antidepressant drug shows burst effect with fluctuating drug levels in systemic circulation due to its higher solubility and shorter elimination half life of 4 hrs. Background: In order to achieve the patient compliance the dose frequency and dose size of VHL can be reduced by entrapping it in gastro-resistant hydrophilic natural polymers. Method: Ionotropic gelation method. Results and Discussion: SEM confirmed cracks on the surface of calcium-alginate microspheres and due to these cracks low drug content and entrapment efficiency was observed. With the increase in the concentration of pectin, a higher number of free carboxylic groups of pectin were able to interact with Ca++ counter-ions and thus increases the drug entrapment. The characteristic peak of VHL was not more detectable in its physical mixture with pectin and sodium alginate due to the strong exothermic effect associated to the pectin decomposition that overlaps and masks the drug fusion peak indicating decrease of crystallinity and uniformity of dispersion at molecular level. The best fit model was Korsmeyer peppas for the formulations (F2-F4) with higher correlation coefficient value, n value, however, appears to indicate a coupling of diffusion and erosion mechanisms so called anomalous diffusion, whereas formulation F1 was best fitted to Higuchi model, indicates diffusion mechanism. Conclusion: Conclusively the optimal formulation comprising of 0.5%w/v VHL, 1.75%w/v sodium alginate and 0.9%w/v pectin was identified to provide maximum % CDR and a controlled drug release profile without burst release extending up to 12 hrs.

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    Author(s) Name:

    Pravin Gupta*, Jeet Singh, Kamla Pathak,

    Affiliation(s) Name:

    Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura (UP), India, 281001

    *Corresponding author.
    Pravin Gupta
    Department of Pharmaceutics
    Rajiv Academy for Pharmacy
    P.O. Chattikara NH # 2,
    Mathura (U.P.), India – 281001
    Email id-

    Received on:08-11-2013; Revised on: 12-12-2013; Accepted on:24-12-2013

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    Pravin Gupta*, Jeet Singh, Kamla Pathak,

    Title:Preparation and evaluation of Venlafaxine hydrochloride Microspheres by Ionotropic Gelation method
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (January )
    Page No: (53-58)
  • Experimental Methods Keywords

    Methodology:Ionotropic gelation method
    Research Materials:Venlafaxine hydrochloride Microspheres


Anti-depressant activity calcium-alginate-pectinate microspheres calcium-alginate microsphere Non-fickian diffusion.

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