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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).

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Journal: Journal of Pharmacy Research , Volume: 10, Issue: December
Article Id: JPRS-PC-00001646
Title: Synthesis, characterization and antibacterial activity of new 5-ethoxy-2-mercapto benzimidazole derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
Author Affiliation: 1Ministry of health-Karbala Health Directorate, Pharmacy Department 2College of Pharmacy-Dept. of Pharmaceutical Chemistry, Bab-Almuadam,Baghdad-Iraq.
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Background: In this study, new derivatives were synthesized from 5-ethoxy-2-mercapto benzimidazole by alkylation, acylation, Schiff base formation and vilsmier-haack reaction (ring closure), and in a good yield. Methods:  The reaction of 5-ethoxy-2-mercapto benzimidazole with different types of alkyl halides to produce S-alkyl derivatives (thioether),1a-c.  The reflux of the parent compound with ethyl bromoacetate, afforded the thioester form of 5-ethoxy2-mercapto benzimidazole derivative, and by treating with benzoyl chloride, lead to the formation of the N-benzoyl thioester form 2. The formation of the thiazolo ring-containing compound 3 was done by equimolar reflux of aliphatic ketone and 5-ethoxy-2-mercapto benzimidazole.The compounds 4a-d  were prepared by the reaction of the parent compound with p-substituted phenacyl bromides, then by addition of 2,4-dinitrophenyl-hydrazine produced the Schiff bases 5a-d.  The pyrazole derivatives 6a-d produced by using vilsmier-Haack reaction, by the treatment of 5a-d with phosphorous oxychloride and DMF. New series of compounds 7a-d and 8  were obtained by the reaction of 4a-d with benzoyl chloride and acetic anhydride, respectively. The antimicrobial activity was evaluated by using Agar Diffusion Well Assay. The four types of bacteria used to evaluate the in-vitro antibacterial activity were Staphylococcus aureus, Streptococcus agalactiae, Pseudomonas aeruginosa and Proteus mirabilis. All the titled compounds characterized and identified by elemental microanalysis, I.R, and 1HNMR spectroscopic study. It was found that all the results showed good agreements with the proposed chemical structures of the synthesized compounds. Results:  All the new compounds have distinctive and highest antibacterial activity against Gram-positive bacteria, especially 6b showed the maximum antibacterial activity against Staph. aureus at a concentration of 100µg/ml,  while the compound 7b exhibited the maximum antibacterial activities against both Gram-positive and Gram–negative bacteria at a concentration of 100µg/ml. Conclusion: The results illustrated good preliminary antibacterial activity of the new 5-ethoxy-2-mercapto benzimidazole derivatives, especially 6b and 7b, against Gram-positive and Gram-negative bacteria.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: December
Article Id: JPRS-HM-00001644
Title: Antianxiety activity of Carissa congesta weight leaves
Category: Herbal medicine
Section: Research Article
Author Affiliation: Gyan vihar University,Jaipur ,Rajasthan,India
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The aim of the present study was to investigate the antianxiety activity of various extracts of Carissa congesta leaves. In the present investigation, leaves of the plant were extracted using solvents in order of increasing polarity viz., petroleum ether (60-800C), chloroform,ethyl acetate and ethanol. All the crude extracts were evaluated for anti-anxiety activity in mice using elevated plus maze apparatus. Among all these extracts, ethyl acetate and ethanolic extract exhibited significant anti-anxiety activity at a dose of 400 mg/kg in mice with respect to control as well as standard (diazepam, 4 mg/kg).It was observed that at the dose of 400 mg/kg dose the Ethyl acetate and Ethanolic extract shows increase the time spent and the number of arm entries in the open arms of the elevated plus-maze. As phytochemical screening of ethanolic extract showed presence of polyphenols, i.e., flavonoids and tannins, thus, these constituents might be responsible for anxiolytic potential of Carissa congesta.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: December
Article Id: JPRS-CPRMS-00001643
Title: Perceptions about oral liquid medication dosing devices and dosing errors by caregivers of hospitalized children
Category: Clinical Pharmacy and Related Medical Science
Section: Research Article
Author Affiliation: Department of Pharmacology and Clinical Pharmacy, K.B. Institute of Pharmaceutical Education and Research, Gh-6, Sector-23, Gandhinagar, Gujarat, India.
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Objective: To evaluate oral liquid medication dosing errors in pediatric patients by his/her caregivers before and after educational intervention and perception about liquid oral medication measuring devices. Material and methods: This was a prospective and experimental study carried out at paediatric ward, Jivraj Mehta hospital Ahmedabad, Gujarat. Dosing measurement accuracy of the parents/guardian was evaluated by proposing them to select different measuring devices (traditional /manual kitchen spoon, scaled cup, syringes etc.) to measure liquid dose of selected liquid medicine. Frequency of preference and ability to measure accurate liquid dose i.e. 5ml were evaluated in pre and post education phase. Likert scale was used to rate the response while % of measuring error was calculated for change in measurement of liquid before and after education. Results: Total 128 respondents participated in study. Respondents’ use of dosing cup (n=116) outnumbered the kitchen spoon (n=2) and oral Syringe (n=10). There was a significant decrease in mean medication error post education compared to pre education (2.23, 7.50, p < 0.0001). Conclusion: Parents/caregivers were more likely to measure an acceptable dose with calibrated dosing cup and cap of the bottle as compared to other measuring devices. Educational intervention is essential to improve liquid dose measurement errors.