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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).

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Journal: Journal of Pharmacy Research , Volume: 14, Issue: April
Article Id: JPRS-PB-00005140
Title: Searching the epitopes in the proteome of Shigella dysenteriae for future vaccine
Category: Pharmaceutical Biotechnology
Section: Research Article
Author Affiliation: Sai Biosystems Private Limited, Nagpur - 440 009, Maharashtra, India.
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Aim: The causative agent of dysentery brought about by Shigella dysenteriae bringing about millions of incidences worldwide and demanded the preventive vaccine by searching potent antigenic candidates. Materials and Methods: S. dysenteriae strain Sd197 proteome screened for outer membrane proteins by involving TMHMM, LipoP, Signal P, and PSORTB server. The surface proteins further selected by BLAST and last searched for epitopes using HLAPRED server. Result: Out of 4582 protein, the best scored 117 antigens recorded by reverse vaccinology approach and reported. Conclusion: The success of reverse vaccinology once again evidenced with reporting of 117 antigens and their epitopes for major histocompatibility complex Class I and II binding. These all nominated for expression and immunological response studies.