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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).

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Journal: Journal of Pharmacy Research , Volume: 4, Issue: April
Article Id: JPRS-MB-00001348
Title: Novel anticancer compounds from marine actinomycetes : A Review
Category: Microbiology
Section: Review Article
Author Affiliation: School of Biosciences and Technology, VIT University,Vellore-632014, Tamilnadu,India
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It is increasingly evident that the true biological origin of many metabolites isolated from certain marine microorganisms. The prokaryotic marine actinomycetes continue to be an important source of bioactive secondary metabolites and potent cytotoxic compounds. These antitumor compounds belong to several structural classes such as polyketides, non-ribosomal peptides, indolocarbazoles, isoprenoides, and others. The medical and pharmaceutical application of these compounds were investigated for a few decades, This review presents a total of 35 anticancer metabolites, belonging mainly to the structural class, which mainly emphasis on their biological activities of the anticancer metabolites against cytotoxic cells isolated from marine actinomycetes from different places between January 2005 and December 2009. This new innovations in the research field will provide valuable and novel insight into the marine actinomycetes dynamics as well as a new approach to comprehending biodiversity which reveals the presents trends on the role of anticancer compounds for the potential lead.

Journal: Journal of Pharmacy Research , Volume: 4, Issue: April
Article Id: JPRS-ND-00001339
Title: Plant natural products: Their pharmaceutical potential against disease and drug resistant microbial pathogens
Category: Natural Drugs
Section: Review Article
Author Affiliation: Department of Zoology,D D U Gorakhpur University, Gorakhpur 273009, U.P. India
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Plants contain diverse groups of phytochemicals such as tannins, terpenoids, alkaloids, and flavonoids that possess enormous antimicrobial potential against bacteria, fungi and other microorganisms. These are much safer than synthetic drugsand show lesser side effects. Approximately 25 to 50 % of current pharmaceuticals are derived from plants. Plant products are  also used for the treatment of skin urinary, cardiovascular and respiratory diseases, which also show antidiarrheal, hepato-protective, hypoglycemic, lipid lowering, antiseptic, and antioxidant activities. Few important plant products such as ellagic acid coumarin, gallic acid, benzenoide, chebulic acid, corilagin, punicalagin, terchebulin, terflabin A-tannin, ellagic acid, ethyl acetate, galloyl glucose and chebulagic acid, triterpenes, flavonoids, quercetin, pentacyclic triterpenoids, guajanoic acid, saponins, carotenoids, lectins, leucocyanidin, ellagic acid, amritoside, beta- sitosterol, uvaol, oleanolic acid and ursolic acid are considered as prominent antimicrobial agents. Natural products also exhibit high susceptibility to drug resistant microbial pathogens such as methicillin- resistant and methicillin- sensitive strains of Staphylococcus aureus. These effectively check proliferation of MRSA. Some of these natural products are used as alternative medicine which are much safer and show lesser side effects than the synthetic drugs. Plant products have ethnopharmacological importance and are used as traditional medicine and food by local tribes.

Journal: Journal of Pharmacy Research , Volume: 4, Issue: April
Article Id: JPRS-PCS-00001353
Title: Determination of Telmisartan and forced degradation behavior by RP-HPLC in tablet dosage form
Category: Pharmaceutics
Section: Research Article
Author Affiliation: NRI Institute of Pharmacy,1,Sajjan Singh Nagar, Opp. Patel Nagar, Bhopal – 462021, M. P.
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A simple, rapid, precise, sensitive and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method for determination of Telmisartan (TELM) in tablet dosage form was developed and validated. Chromatographic separation was achieved on a 250 × 4.6 mm, 5μ, Waters symmetry column in gradient mode, with mobile phase consisting of a mixture of solution (10 mM potassium dihydrogen phosphate, pH 3.5 ± 0.01): acetonitrile (64:40) was used. The quantitation performed at flow rate of 1.0 mL/min at 230 nm and run time was 12 min. The analytical method was validated as per ICH guideline for linearity, accuracy, precision, specificity, limit of detection, limit of quantification, robustness and stability and method can be extended to the analysis of TELM in tablet formulations. The relative standard deviation values for precision was less than 2%, and % recovery was greater than 98% for TELM. The drug undergoes oxidative degradation, thermal degradation and in alkali medium.