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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).

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Journal: Journal of Pharmacy Research , Volume: 5, Issue: May
Article Id: JPRS-PHDRS-00001205
Title: Antiviral activity of plant polyphenols
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Author Affiliation: Chandigarh college of Pharmacy, Landran, Mohali, Punjab, India
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Polyphenols are plant secondary metabolites and are commonly found in fruits, vegetables, food grains, seeds, flowers, tea, wine, honey and forages. For centuries, preparations containing these compounds as the principal physiologically active constituents have been used to treat human diseases. A number of traditional plant derived folk medicines rich in polyphenols used from earliest times to cure disorders of the blood stream including blood pressure, antiviral effects, stomach disorders, antiseptic action, dressing of burns and inflammation and inhibition of direct acting mutagens. Phenols and bioflavanoids are the major classes with antiviral activity against various diverse virus families such as retroviridae, hepadnaviridae, hespervirides, HIV virus, influenza virus, herpes simplex virus, dengue virus, polio virus etc. For antiviral activity presence of hydroxyl group and ester groups are necessary. The phenolics with five and more hydroxyl groups and 3, 4, 5-three methoxy derivatives show anti-viral and anti-rabies activity while alkyl-esters of gallic acid (gallates), epicathechin responsible for anti-herpetic activity. These compounds represent novel leads, and future studies may allow the development of a pharmacologically acceptable antiviral agents or class of agents. In this review, plant polyphenols as antiviral agent, different sites of its antiviral action, evaluation methods of its antiviral properties and various phenolic components isolated from plants with antiviral activities are outlined and discussed.

Journal: Journal of Pharmacy Research , Volume: 5, Issue: May
Article Id: JPRS-PB-00001204
Title: Effect of lead toxicity on the growth and antioxidant enzymes in Helianthus annuus.L seedlings
Category: Pharmaceutical Biotechnology
Section: Research Article
Author Affiliation: Department of Biotechnology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati-517502, Andhra Pradesh, India.
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Helianthus annuus-L plants were grown in soil supplemented with different lead concentrations (0, 5, 10, 15, 20, 25 and 30 ppm). Germination percentage was remained un affected at low concentration of metal as compared to control plants but at higher concentration i.e., 20 ppm onwards Germination was inhibited. Growth was also decreased as concentration of metal was increased as compared to control plants. Photo synthetic pigments, chlorophyll content as well as soluble protein content decreased as concentration of metal was increased in comparison with control plants. In order to investigate whether lead induces common plant defense path ways, the temperal sequence of different biochemical reactions including lipidperoxidation and the activities of some antioxidant enzymes such as SOD, CAT, GPOx,GRX were studied in both leaves and roots of Helianthus annuus.L. Results showed that there was increase in the activities of LPX, GPOX, SOD and GRX and decrease in, CAT activities. Finally the obtained results in this study suggest that growth of sunflower plants in the presence of lead metal showed a concentration –dependent oxidative stress situation in both leaves and roots as a result of the inhibition of the antioxidant systems.