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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).

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Journal: Journal of Pharmacy Research , Volume: 9, Issue: September
Article Id: JPRS-P'Col-00001110
Title: Evaluation of Combinational Therapy of Resveratrol and Black Tea Extract on Doxorubicin-induced Myocardial Infarction in Wistar Rats
Category: Pharmacology
Section: Research Article
Author Affiliation: Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India
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Background: Cardiovascular and cancer problem is increasing day by day and causing untimely deaths worldwide. A continuous research is going on to develop new cardioprotective and anticancer drugs which are safe, economical and effective. Doxorubicin is a potent anticancer drug with restricted use due to cardio toxicity that it causes as side effect. Thus, any drug which will reduce its toxicity will be a boon for cancer patient. Herbal drugs are emerging as potent targets for research because they are cheap, locally available; having least reported side effects and generally being the part of our food culture. In view of this we have tried to evaluate the cardioprotective potential of resveratrol and black tea extract alone and in combination on the doxorubicin-induced myocardial infarction in rats. Methods: Thirty rats of Wistar albino strain were taken and divided into Control, Doxorubicin (DOX), Black Tea + DOX, Resveratrol + DOX, Black Tea + Resveratrol and Black Tea + Resveratrol + DOX treated groups. Various biochemical parameters were assessed to evaluate their antioxidant property and myocardial membrane integrity. Effect of these neutraceuticals on cellular architecture was also assessed by histopathological studies. Results and Discussions: Biochemical and histopathological investigations clearly showed the reversal of all the parameters towards normal indicating improvement in antioxidant status and reduction in cardiac damage. Conclusion: All the test drugs administered groups ; black tea-treated, resveratrol-treated and their combination-treated groups, showed cardio protection but the combination-treated group proved to be a better cardioprotective agent than the two drugs alone.

Cite this article as: Ahmad Amanullah, Rustam Ekbbal and Syed Ehtaishamul Haque,Evaluation of Combinational Therapy of Resveratrol and Black Tea Extract on Doxorubicin-induced Myocardial Infarction in Wistar Rats,Journal of Pharmacy Research 2015,9(9),581-587

Journal: Journal of Pharmacy Research , Volume: 9, Issue: September
Article Id: JPRS-PC-00001106
Title: Application of Quality by Design in the Synthesis of 6-substituted-2-aminobenzothiazole
Category: Pharmaceutical Chemistry
Section: Research Article
Author Affiliation: School of Pharmacy & Technology Management, SVKM’s NMIMS, Shirpur- 425405,Dist. Dhule, Maharashtra (India)
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Background: 6-chloro-2-aminobenzothiazole is a key starting material for synthesis of many APIs. Literature reveals that synthesis of 6-chloro-2-aminobenzthiozole requires more time while giving poor yield. Therefore the purpose of this study was to achieve better yield & purity by application of QbD approach. Methods: The reaction was studied for effect of temperature and effect of light during the bromination and cyclization step. Each of the focus areas and process parameters were assessed for the likely risk they pose to the quality and yield (the CQAs) of the final product, 6-chloro-2-aminobenzothiazole. The reaction was optimized using Design of Experiment. Temperature and intensity of light were selected as the independent variables. The effect of the independent variables on the % yield, % purity and reaction time was studied. Results: The design space was developed between CPPs and CQAs of the focus area, i.e., Bromination, to facilitate the process of predicting the extent of effects of CPPs over CQAs. After a good understanding of the reaction mechanism, experimental and statistical evaluation of the results, it was found that temperature shows a significant effect on all the three CQAs whereas reaction time was governed by both temperature and intensity of light. Conclusion: The reaction was optimized using graphical and numerical evaluations and was found to best fit in terms of a reaction carried out in ice bath at 0oC and a 100W bulb. More scope for improvement was found in terms of application of DoE to the Recrystallization step.

Cite this article as: Chandrakant Bonde, Deepti Vedala, Smita Bonde,Application of Quality by Design in the Synthesis of 6-substituted-2-aminobenzothiazole,Journal of Pharmacy Research 2015,9(9),573-580

Journal: Journal of Pharmacy Research , Volume: 9, Issue: September
Article Id: JPRS-Pe-00001108
Title: Comparison of various techniques for measuring alveolar ridge dimensions prior to implant placement - A pilot study
Category: Periodontics
Section: Research Article
Author Affiliation: Department of periodontics, Saveetha Dental College and Hospitals, No:162, Poonamalle High Road, vellapanchavadi, Chennai 600 077,Tamilnadu,India.
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Background: Implants are becoming the future trend for replacement of missing teeth. The surgical procedure requires prior treatment planning and knowledge of the surgical site. The present study was conducted to assess and compare various techniques that are used for the measurement of alveolar ridge dimensions prior to treatment planning for implants. Aim: The aim of this study was to compare direct intra-operative ridge measurements (DIRM) using vernier calipers to measurements taken by alveolar ridge mapping (RM) ,Computed Tomography (CT) and Cone-Beam Computed Tomography (CBCT) for measuring alveolar bone dimensions prior to implant placement. Material and Methods:. An acrylic stent was prepared for each patient. The acrylic stent provided buccal, lingual and crestal sites for consistent measurements of alveolar ridge dimensions through ridge mapping (RM). A conventional CT and CBCT were taken and these three techniques were compared to DIRM. Statistical analysis used: The study data were analyzed using one sample T- test to compare the mean absolute difference with 0. Pearson’s correlation was used to assess the linear relationship with DIRM. Comparisons were made between RM, CT, CBCT with DIRM using a Bland-Altman plot and pictorially represented with a bar plot. Results: Data were compared using bar graph. RM was found to have more correlation to DIRM than the other techniques. However CBCT had lesser variations from DIRM when compared to a conventional CT. The latter two techniques, that is, CT and CBCT are useful for 3-dimensional information of the surgical site prior to implant placement.Conclusion: Ridge mapping can be used effectively for measurement of alveolar bone width. Additional information about the surgical site can be obtained from a conventional CT or a CBCT.

Cite this article as: Archana Mootha, Sankari Malaiappan, Sheeja.S.Varghese, N.D.Jayakumar,Gurumoorthy Karthikeyan,Comparison of various techniques for measuring alveolar ridge dimensions prior to implant placement - A pilot study, Journal of Pharmacy Research 2015,9(9),593-596.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: September
Article Id: JPRS-MB-00001107
Title: Genome of Acinetobacter baumannii Carries Multi Drug Resistance Genes
Category: Microbiology
Section: Research Article
Author Affiliation: Department of Microbiology, Taywade College, Koradi, Nagpur, India
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Background: The study conducted to determine resistant and virulent genes in multi drug resistance Acinetobacter baumannii. Aim: A. baumannii has emerged as an important human pathogen in hospitalized patients, and leads to increased infection with significant morbidity and mortality. The study aimed to confirm the presence of resistance and virulent genes in multidrug resistance strains of A. baumannii. Methods: The multidrug resistance was screened for the several strains of A. baumannii and two strains Aba03 and 04 was used for screening the marker presence of gyrA, blaOXA-51, ISAba1-A, ampC-AB and strB in the genome using polymerase chain reaction. Results and Discussion: A. baumannii found to be positive for the marker genes gyrA, blaOXA-51, ISAba1-A and ampC-AB and negative for strB gene in both the strains. Conclusion: This report highlights the functions of novel resistant and virulent determinants, in bringing drug resistance in A. baumannii.

Cite this article as: Jimmy B. Vaidya, Vijay N. Charde,Genome of Acinetobacter baumannii Carries Multi Drug Resistance Genes,Journal of Pharmacy Research 2015,9(9),588-592