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Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . From 2019  Journal will be monthly twice ( vol 11& 12 with 2 Issues per month)
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.895 as on date (09.11.2018)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 2, Issue: March
Article Id: JPRS-PS-0000931
Title: Evaluation of wound-healing activity of Eichornia crassipes: A novel approach
Category: Pharmacological Screening
Section: Research Article
Author Affiliation: Department of Research Jawaharlal Nehru Cancer Hospital & Research Centre,Idgah Hills,Bhopal 462001 India.
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There are no experimental reports on wound healing activities of Eichornia crassipes in literature. In this article, we report for the first time, the efficacy of Eichornia crassipes extract in the treatment of wounds. The methanolic extract of Eichornia crassipes leaves were investigated for the evaluation of their wound healing potential on excision experimental model of wounds in rats. The methanolic extract of leaves of Eichornia crassipes, in the form of an ointment with two different concentrations (10% and 15% w/w ointment of leaf extract in simple ointment base) was evaluated for wound healing potential in an excision wound model in rats. It is observed that the wound contraction ability of the ointment containing Eichornia crassipes extract in different concentrations was significantly greater than that of the control (simple ointment). The 15%w/w extract containing ointment group showed significant wound healing from the fourth day onwards which was comparable to that of the nitrofurazone ointment treated animals. The wound closure time was less and the percentage of wound contraction was much more with the 15%w/w extract ointment treated group. On 18th day 100% contraction was observed which was almost similar to that of the nitrofurazone ointment group. 10%w/w extract ointment group of animals showed significant wound contraction from the 18th day onwards and achieved 100% with the wound closure time of 20th days. Both concentrations of the methanolic extract of Eichornia crassipes ointment showed significant responses when compared with the control group. The effect produced by the extract ointment, in terms of wound contracting ability, wound closure time, regeneration of tissues at wound site, and histopathological characteristics were comparable to those of a standard drug nitrofurazone ointment. Thus, this investigation confirms the use of the Eichornia crassipes ointment as a wound-healing agent.

Journal: Drug Invention Today , Volume: 2, Issue: March
Article Id: JPRS-ADRS-0000928
Title: Antileprotic Potential of Ethnomedicinal Herbs: A Review
Category: Ayurvedic Drugs Related Study
Section: Review Article
Author Affiliation: 1National Institute of Ayurvedic Pharmaceutical Research, CCRAS, Dept. of AYUSH Patiala, India
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The World Health Organization estimates that about 80% of the population of most developing countries relies on herbal medicines for their primary health care needs. Presently there are many medicinal herbs under investigation for their potential health protection. Among the products under investigation are commonly consumed products like vegetables, fruits and condiments expected to protect health and possess disease inhibiting properties like leprosy which caused by Mycobacterium leprae. This review therefore attempts to bridge the existing literature and modern research and offers immense scope for researchers engaged in validation of the traditional claims and development of safe, effective and globally accepted herbal drugs for treatment of leprosy.

Journal: Drug Invention Today , Volume: 2, Issue: March
Article Id: JPRS-PS-0000929
Title: Anticonvulsant Activity of whole parts of Sphaeranthus indicus Linn. Extract in Experimental Mice
Category: Pharmacological Screening
Section: Research Article
Author Affiliation: Dadhichi College of Pharmacy, Sundergram, Cuttack-754002, Orissa.
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Purpose: The aim of the present study was to investigate anticonvulsant effect of the Petroleum ether, Benzene, Chloroform, Ethanol and triple distilled water extract of whole parts of the plant of the Sphaeranthus indicus Linn. (Compositae) on electrically and chemically induced seizures.Methods: The Petroleum ether, Benzene, Chloroform, Ethanol and water extract of the whole parts of the plant of S.indicus (200 and 400 mg/kg, i.p.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and pentylenetetrazole-, picrotoxin-, bicuculline- and N-methyl-dl-aspartic acid-induced seizures in mice. The latency of tonic convulsions and the number of animals protected from tonic convulsions were noted. Results: Ethanol extract (200- 400 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES). However, only 200 and 400mg/kg of the extract conferred protection (25 and 50%, respectively) on the mice. The same doses also protected animals from pentylenetetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures produced by picrotoxin and N-methyl-dl-aspartic acid. The extract had no effect on bicuculline-induced seizures. The aqueous extract (400mg/kg) significantly reduced the latency, but did not alter the incidence of seizures elicited by maximal electroshock to any significant extent. Conclusion: The data suggest that the ethanolic root extract of S.indicus may produce its anticonvulsant effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by pentylenetetrazole and picrotoxin.

Journal: Drug Invention Today , Volume: 2, Issue: March
Article Id: JPRS-BSN-0000930
Title: In vivo and in silico studies with the latex of the milk weed- Calotropis procera (Ait) R.Br
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
Author Affiliation: Research Scholar, Mother Teresa Women’s University, Kodaikanal- 624 102
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The toxic milk weed-Calotropis procera has gained popularity in scientific research with the increased awareness of its uses in different areas of applications. Insufficient knowledge about the molecular mechanism of this plant’s latex in vivo limits the scope of their application and hinders the effort to design new drugs from Calotropis sp. To study first pass metabolic effect in vivo,plasma from Wistar albino rats (after dosing with aqueous extract of dried latex (DL) of C. procera at 300mg/kg bodyweight either alone or in combination with 10% Fructose in drinking water), were analyzed with electrospray tandem mass spectrometry coupled to liquid chromatography (ESI-LC-MS/MS) to obtain metabolite changes by global profiling of low molecular weight metabolites. To provide insight into assessing new initiatives required to manipulate human physiology in cases of accidental exposure to latex, in this study, compounds of Calotropis latex were docked with receptors of Renin Angiotensin System (RAS) and the binding residues were identified. This study would facilitate our understanding of the role of these elicited low molecular metabolites in disease and toxicity and the identified binding amino acid residues would assist in drug development from Calotropis compounds.