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Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . From 2019  Journal will be monthly twice ( vol 11& 12 with 2 Issues per month)
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.895 as on date (09.11.2018)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 3, Issue: September
Article Id: JPRS-MSNS-00001086
Title: Mitochondrial DNA and Inherited Diseases – A Comprehensive Review
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Review Article
Author Affiliation: Faculty of Microbiology, Saveetha Dental College, Velappanchavady, Chennai-77
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Mitochondria are membrane-bound organelles located in the cytoplasm of the cell. They are the sites of cellular respiration which ultimately generates fuel for the cell's activities. Mitochondria are the only non-nuclear constituents of the cell with their own DNA (mtDNA) and machinery for synthesizing RNA and proteins. Mutations in the mitochondrial genome have been implicated with a wide range of age-related pathologies, cancers, neurodegenerative diseases and in general, processes that regulate cellular and organismal aging. There has been considerable progress in understanding the role of mtDNA mutations in human diseases during the last two decades, but important mechanisms in mitochondrial genetics remain to be explained at the molecular level. This review gives an overview of mitochondrial DNA structure and function and then outlines more specifically the metabolic and molecular alterations in mitochondria, associated with human diseases and their clinical implications.