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Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . From 2019  Journal will be monthly twice ( vol 11& 12 with 2 Issues per month)
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.895 as on date (09.11.2018)
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Journal: Drug Invention Today , Volume: 3, Issue: March
Article Id: JPRS-D(DD)-0000887
Title: Nasal Drug Delivery Systems: Scope And Potential
Category: Drug (Discovery/Development)
Section: Review Article
Author Affiliation: DIT- Faculty of Pharmacy, Dehradun-248001, Uttarakhand, India
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The administration of drugs through the nasal cavity is not a new method of delivering drugs. It has been used of the delivery of psychotherapeutic compounds in the ancient era, particularly for the systemic effects. The increasing research in the field of pharmaceutics has led to the development of a number of formulations for the systemic drug delivery. The drug delivery through the nasal mucosa provides a number of advantages like an large surface area for absorption, overcomes the first pass effect. The increasing research in the field of novel drug delivery system has led to the development of novel forms like the intranasal route which has been shown to have an equivalent efficacy to the intravenous route. The nasal drug delivery system is very advantageous in the delivery proteins, peptides and the novel research in the field has led to the development of nose to brain drug delivery systems. The use of the strategies which enhance the nasal bioavailability are being used to formulate a number of drugs for delivery via the nasal route. The present article focuses on the recent trends in the intranasal drug delivery, formulation approaces, bioavailability considerations and the evaluation parameters.

Journal: Drug Invention Today , Volume: 3, Issue: March
Article Id: JPRS-PS-0000888
Title: Hypoglycaemic activity of a polyherbal product in alloxan induced diabetic rats
Category: Pharmacological Screening
Section: Research Article
Author Affiliation: *1Faculty, 2 MBBS student, fifth semester, 2 Postgraduate students, Department of pharmacology, Kasturba Medical College, Manipal University, Mangalore-575001. INDIA.
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Background: Ayurveda, an ancient Indian system of medicine, mentions several plants that are useful in the correction of metabolic disorders such as diabetes mellitus. Plants have been exemplary source of drugs in the treatment of diabetes mellitus [DM]. Many of the currently available drugs have been directly or indirectly derived from them. In spite of being hundreds of claimants none have gained enough momentum in clinical practice as most of them lack scientific validation. YXK12 is a commercially available polyherbal product recently introduced in the market and manufacturers claim the product to have anti diabetic properties. This study was undertaken to evaluate the hypoglycaemic effect of this drug in Alloxan induced diabetic rats. Materials and methods: Alloxan monohydrate is used to induce diabetes mellitus in Wistar rats. Hypoglycemic effect of two doses of the drug YXK12 is evaluated in these rats and the results are compared to the effects of a placebo and the standard hypoglycaemic drug Glibenclamide. Results: Blood glucose lowering effect of YXK12 in the higher dose of 2000mg/kg was found statistically significant [p=0.001]. Lower dose of did not show statistically significant hypoglycaemic effect when compared to placebo control. Conclusion: The dose which has produced hypoglycaemic effect in rats is equivalent to the highest doses of the product recommended for patients of diabetes mellitus. This dose [2000mg/kg in rats] if converted to human dose is equivalent to highest human dose recommended. As lower doses have not demonstrated any hypoglycemic activity, lower doses in humans needs to be evaluated.

Journal: Drug Invention Today , Volume: 3, Issue: March
Article Id: JPRS-D(DD)-0000889
Title: Formulation and Evaluation of Gastro retentive Floating Drug Delivery System of Ofloxacin
Category: Drug (Discovery/Development)
Section: Research Article
Author Affiliation: University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.
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The objective of this present study is to formulate and evaluate the gastroretentive floating drug delivery system (GRFDDS) of ofloxacin prepared by using synthetic and natural polymers (polyethylene oxide and gum karaya). Formulations were prepared by wet granulation technique and sodium bicarbonate (10% w/w) was incorporated as gas generating agent. Tablets were evaluated for hardness, in vitro buoyancy, drug content and in vitro drug release studies. Release data obtained was subjected to analysis using different mathematical models namely – zero order flux, first order, erosion plot, Higuchi and Korsmeyer peppas equations. All formulated tablets irrespective of polymer used had hardness and friability values >5.0kg/cm2 and <0.68%. The in vitro lag time and total buoyancy time for all the formulations
were between 45 to 183secs and 5 to 16 hrs respectively. As the concentration of the polymers in the formulations increased the drug release decreased. Formulations made with gum karaya exhibited first order kinetics, non- fickian diffusion and the formulations like OGK3 and OGK4 followed first order and erosion mechanism. Whereas polyethylene oxide based formulations OP2,OP4 and OP5 exhibited zero order, non fickian diffusion and remaining formulations followed first order, erosion mechanism. GRFDDs of ofloxacin using synthetic (polyethylene oxide) and natural polymer (gum karaya) with drug to polymer ratio 1:0.5 and 1: 0.625 respectively are final optimized formulations. These were further characterized by Fourier transform infrared spectroscopy (FTIR) which indicated that there was no interaction
between drug and polymers.

Journal: Drug Invention Today , Volume: 3, Issue: March
Article Id: JPRS-PS-0000890
Title: Antioxidant activity of melanin pigment from Streptomyces species D5 isolated from Desert soil, Rajasthan, India
Category: Pharmacological Screening
Section: Research Article
Author Affiliation: 1Postgraduate Department of Microbiology, Sri Sankara Arts & Science College, Kanchipuram – 631 561 (T.N.) India
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The present study reports antioxidant activity of melanin pigment from actinomycete strain D5 isolated from Thar Desert soil, Rajasthan, India. Melanin production by the strain D5 was confirmed using tyrosine agar. Melanin production was carriedout by adopting solid state fermentation using wheat bran and rice bran medium and extracted using ethyl acetate. About 280 mg/10 gram and 192 mg of crude pigment were extracted from 10 gram of wheat bran and rice bran medium, respectively. The melanin pigment from crude extract was partially purified by preparative TLC and the purified melanin fraction showed good free radical scavenging activity in DPPH method. The actinomycete strain D5 was characterized and identified as Streptomyces girseorubiginosus (D5) based on their phenotypic characteristics. Further fermentation and purification of melanin pigment from strain D5 will leads to a development of pharmaceutically valuable antioxidant.

Journal: Drug Invention Today , Volume: 3, Issue: March
Article Id: JPRS-MSNS-0000891
Title: Antibacterial activity of ethanolic leaf extract of Rauwolfia tetraphylla (Apocyanaceae) and its bioactive compound reserpine
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
Author Affiliation: PG and Research Dept of Botany, National College, Tiruchirappalli - 620 001, India.
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In vitro antibacterial activity of ethanolic leaf extract of Rauwolfia tetraphylla was studied against selected pathogenic bacteria Bacillus cereus, Escherichia coli, Staphylococcus aureus and Yersinia enterocolitica by disc diffusion assay. Bioactive compound reserpine was isolated from the leaf. The results revealed that the ethanolic leaf extract and reserpine compound are potent in inhibiting these bacteria which cause gastroenteritis in human population. This work highlights that the inhibitory effect is on par with standard antibiotics.