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Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . From 2019  Journal will be monthly twice ( vol 11& 12 with 2 Issues per month)
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.895 as on date (09.11.2018)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 7, Issue: March
Article Id: JPRS-D(DD)-0000694
Title: Pharmacokinetic and Pharmacodynamic Evaluations of Aceclofenac Matrix sustained release Tablets using Natural gum
Category: Drug (Discovery/Development)
Section: Research Article
Author Affiliation: Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
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Background: This study was undertaken to develop and formulate aceclofenac matrix sustained release tablets using a natural gum and to conduct its pharmacokinetic and pharmacodynamic evaluation. Methods: Sustained release matrix tablets of aceclofenac were prepared by using a direct compression technique, using Salmalia malabarica gum as matrix forming material while microcrystalline cellulose was as filler. All the ingredients were passed through a # 20 sieve, weighed, and blended. These formulations were compressed with a single station tablet compression machine using 9 mm flat faced punches. Results and discussion: The drug–polymer interactions were studied using FT-IR spectroscopy which indicated the absence of interactions. Scanning electron microscopy was used to visualize the surface morphology of the tablets and confirm drug release mechanisms. The stability studies were performed using ICH guidelines for a period of six months and found that the developed formulation was stable. In-vivo studies for anti-inflammatory activity and pharmacokinetics were performed in wistar rats and young male rabbits respectively. The in-vivo results showed that the optimized tablet (F-5) exhibited significant difference in the drug release in comparison to that of pure drug and marketed formulation. Conclusion: It can be concluded that the developed formulation shows sustained release and is of cost effective for the formulation development of aceclofenac tablets.

Journal: Drug Invention Today , Volume: 7, Issue: March
Article Id: JPRS-BSN-0000910
Title: Phytochemical and Pharmacognostical Studies on Murraya koenigii (L)spreng. Roots
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
Author Affiliation: Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala NH-64, Rajpura, Patiala-140401, Punjab, India
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The Murraya koenigii plant is widely used as herb, spice, condiments and also used to treat various types of ailments in Indian traditional system. Worlds about 80% population relies upon herbal products, because they have been considered as safe, effective and economical. The present study was aimed to set standard parameters for standardization of Murraya koenigii roots. In the present study microscopy of root and roots powder carried out, ash values, extractive values, fiber content, bitterness value, haemolytic activity, tannin content and roots powder fluorescence nature also observed using different chemical reagents. The alcoholic and aqueous extracts were screened for presence of amino acid and carbohydrates. The preliminary phytochemical screening of petroleum ether extract, ethyl acetate extract, chloroform extract, ethanol extract and aqueous extract was performed. The presence of alkaloids, flavonoids, carbohydrates, and sterol in various extracts were observed. This is first ever pharmacognostical study carried out on Murraya koenigii roots.

Journal: Drug Invention Today , Volume: 7, Issue: March
Article Id: JPRS-BSN-00001104
Title: Anticonvulsant And Antioxidant Actions Of Some Dibenzo-a-Pyrone Derivatives In Pentylene –Induced Kindling Model In Mice
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
Author Affiliation: ITS paramedical (Pharmacy) College, Muradnagar, Ghaziabad, Uttar Pradesh, 201206 India
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Objective: The present study was carried out to investigate the effect of Dibenzo-α-pyrone derivatives on the course of pentylenetetrazole (PTZ)-induced chemical kindling and oxidative stress markers in PTZ-kindled mice. Methods: Kindling was induced by repeated injections of a subconvulsive dose of PTZ (25mg/Kg, i.p.) on alternate days for 5 weeks or until stage 5 of the seizure score was evoked on three consecutive administrations. Butylamine, Diethylamine and Pyrrolidine Derivatives of Dibenzo-α-pyrone were administered daily in three doses (10, 20 and 40mg/kg) per orally (p.o.) along with alternate day PTZ. Following PTZ kindling , oxidative stress parameters , i.e. levels of malondialdehyde (MDA) and reduced glutathione (GSH), were assessed in isolated homogenized whole brain tissue. Results: PTZ treatment progressively increased the seizure score in control mice. Biochemical analysis revealed a significant increase in MDA levels and decreased GSH levels in the brain homogenate of PTZ-kindled mice. Daily treatment with Butylamine, Diethylamine and Pyrrolidine Derivatives of Dibenzo-α -pyrone in doses of 20 and 40mg/kg significantly decreased the PTZ-induced seizure score. However, a low dose (10mg/kg) failed to improve the seizure score. Pretreatment of derivatives in all doses showed an ameliorating effect on biochemical alteration induced by PTZ treatment. Conclusion: The present study indicate the potential anticonvulsant activity of Dibenzo-α-pyrone derivatives against PTZ-induced kindling in mice.