Journal Menu


Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . From 2019  Journal will be monthly twice ( vol 11& 12 with 2 Issues per month)
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.895 as on date (09.11.2018)
Indexed in
NCBI NLM Catalogue,
SCOPUS, EMBASE (Elsevier),
ROAD, CABI, Google Scholar,
Open J-Gate, Biblioteca,
Science Central,
Index Scholar, Indian Citation Index,
 AYUSH Research Portal, 
Indexed Copernicus, EBSCO, PSOAR,
Ulrichs Directory of Periodicals, etc.

Manuscripts Published

Journal: Drug Invention Today , Volume: 9, Issue: September
Article Id: JPRS-PS-00001828
Title: Infusion of adrenomedullin22-52 antagonist causes uteroimplantation growth restriction during early gestation in rats
Category: Pharmacological Screening
Section: Research Article
Author Affiliation: Department of Biotechnology, Sri Padmavati Mahila Visvavidyalayam (Women’sUniversity), Tirupati - 517 502, Andhra Pradesh, India.
View Article

Background: The present study exploited whether antagonism of endogenous Adrenomedullin (ADM) in rats during early gestation period resulted in diminished uterus and implantation growth and explored whether this causes through induction of apoptosis. Rats on gestational day 2 were implanted subcutaneously with osmotic (ALZET) minipumps delivering 125 and 250 µg/rat/day/of ADM22-52 and were killed on gestational day 9. On gestational day 9, both in the control group rats and ADM antagonist-treated rats, 5-bromo 2´deoxyuridine labeling dye is injected in the tails of rats with a concentration of 1 ml/100 g body weight and then sacrificed the animal. We have demonstrated that the uterus growth and implantation development are seriously compromised by this modest decrease in expression and the implanted sites were shown prominently by blue-/purple-colored spots both in control and ADM-treated groups. Results: Apoptotic variations were more evident in stromal trophoblastic cells in the uteroimplantation sites of ADM22-52-treated rats when compared with vehicle control rats. Immunoreactivity to active caspase-3, Bax, Bcl2 protein was abundant in the uteroimplantation regions of the ADM22-52-treated group. Conclusion: These findings, however, show that antagonism of ADM in rats during early pregnancy caused uteroimplantation growth restriction and increased fetal resorption through the activation of mitochondrial apoptotic pathways.

Journal: Drug Invention Today , Volume: 9, Issue: September
Article Id: JPRS-PS-00001830
Title: Evaluation of combined wound healing activity of ethanolic extracts of leaves of Murraya koenigii and Nyctanthes arbortristis on rats
Category: Pharmacological Screening
Section: Research Article
Author Affiliation: Department of Pharmacognosy, Mula Education Society’s College of Pharmacy, Sonai, Newasa, Ahmednagar - 414 105, Maharashtra, India
View Article

Objective: The present work was executed to evaluate the wound healing potency of a combined preparation of two plant extracts. The objective of this study is to induce experimental wounds using excision and incision wound model in normal albino wistar rats and to study the wound healing activity of prepared combined formulation by comparison of changes in wound healing between experimental and placebo controlled rats. Methods: The individual ethanolic extract of Murraya koenigii and Nyctanthus arbortrstis was investigated for preliminary phytochemical study. Then the effect of combined ointment formulation containing equal quantity of ethanolic extracts of leaves of Murraya koenigii and Nyctanthus arbortrstis was investigated by using excision and incision wound model in rats. Results: Both the extracts show presence of phytochemicals responsible for wound healing activity. The herbal ointment formulation 3 was found to be significantly reducing wound area, epithelization period and wound contraction rate. Similarly this formulation also shows significant increase in wound breaking strength. Conclusions: The study shows capability of both the extracts to promote accelerated wound healing activity by dose dependant manner when compared with placebo control.

Journal: Drug Invention Today , Volume: 9, Issue: September
Article Id: JPRS-PS-00001827
Title: In vivo antiplasmodial evaluation of syzygium jambos L. Alston by four day suppressive test
Category: Pharmacological Screening
Section: Research Article
Author Affiliation: PG and Research Department of Microbiology, Dr. N.G.P. Arts and Science College, Coimbatore - 641 048, Tamil Nadu, India
View Article

Objective: The unexplored region of Western Ghats possesses natural source of noble therapeutic floras for many diseases. The present study was aimed to investigate the in vivo antiplasmodial activity of Syzygium jambos from Western Ghats. Methods: The four extracts acetone, chloroform, methanol and aqueous were explore their antiplasmodial activity by Peter’s four day test. Results: In Peter’s four day test significant parasite suppression 99.24% (P<0.001) was observed in Chloroquine (CQ 25mg/kg b.wg.) group prolonging the mean survival time of animals ≥30 days, whereas no average parasitaemia suppression (44.33±0.94) was observed in the negative control group. An effective parasite suppression (P<0.01) of 72.93% and 72.18% was identified in methanol and acetone extracts respectively at 600 mg/kg b.wt. The acetone and methanol extracts prolonged the mean survival days of mice groups up to 27.8 ± 0.68 and 26.0 ± 1.29 days respectively. Conclusion: Among the four extracts tested methanol and acetone extracts exhibited antimalarial activity. The present study report establishes, Syzygium jambos leaf extracts were effective with an assorted range of antiplasmodial activity and could be a potential source in the discovery of antimalarial drug.

Journal: Drug Invention Today , Volume: 9, Issue: September
Article Id: JPRS-D(DD)-00001826
Title: Validation of water system: A review
Category: Drug (Discovery/Development)
Section: Review Article
Author Affiliation: Department of Pharmacy Practices, Division of pharmaceutical Sciences, Shri GuruRam Rai Institute of Technology and Science, Patel Nagar, Dehradun - 248 001, Uttarakhand, India
View Article

Water is essential for industrial, pharmaceutical, and hospital purposes, in the preparation and processing of medicines and other health products and for cleaning and hygiene purposes. A supply of clean water is an essential requirement for the establishment and maintenance of diverse human activities. Water resources provide valuable food through aquatic life and irrigation for agriculture production. Steps involved in the validation of the pharmaceutical water system are; design qualification, installation qualification, operational qualification, and performance qualification. Validation of the water system should be performed time to time so as to prove its reliability and robustness of the system for producing water of specified quality with a high degree of assurance and every report should be documented for better work. This review is an attempt to discuss about the various aspects of validation of water system.

Journal: Drug Invention Today , Volume: 9, Issue: September
Article Id: JPRS-DFA-00001971
Title: Self-microemulsifying drug delivery system for enhancement of oral bioavailability of losartan
Category: Drug or Formulation Analysis
Section: Research Article
Author Affiliation: Department of Pharmaceutics, MES College of Pharmacy, Affiliated to Savitribai Phule Pune University, Sonai, Newasa, Ahmednagar, Maharashtra, India
View Article

Objective: The objective of the present study was to formulate self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability of losartan. Experimental: The solubility of losartan was determined in various vehicles, and pseudoternary phase diagrams were used to assess the micro-emulsification boundary. The losartan SMEDDS was prepared using Capmul MCM EP (oil), tween 80 (surfactant), and polyethylene glycol (PEG) 400 (cosurfactant). Results: The SMEDDS was tested for microemulsifying properties, and the resultant microemulsions were evaluated for droplet size, zeta potential, transmission electron microscopy, and in vitro dissolution. The formulation development and screening were done on the basis of results obtained from phase diagrams and characteristics of resultant microemulsions. The selected formulation of Capmul MCM EP with surfactant and cosurfactant mixture (Smix) ratio of 1:1 (Tween-80: PEG-400) subjected to in vivo bioavailability study using rabbit. The results of drug release and oral bioavailability of losartan SMEDDS were compared with marketed formulation. The selected formulation enhanced the oral bioavailability of losartan by 1.49 folds than the marketed formulation.